Some studies have suggested that anxiety is a common manifestation at the diagnostic stage of patients with ALS. Once diagnosed, the majority of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) patients present anxiety-depressive disorders and even suicidal reflections. These symptoms negatively affect their quality of life, and higher depressive scores have been associated with accelerated disease progression.
A large-sample study investigating a possible association between anxiety-depressive disorders in ALS/MND in the People’s Republic of China was recently conducted. The study was published in Neuropsychiatric Disease and Treatment journal.