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    • #16049
      ed
      Participant

      Hi all,

      Has anyone used Deanna AAKG and if so did it help improve energy, strength or reduce fatgue?

      Thanks

    • #16050
      Dagmar
      Keymaster

      The Deanna Protocol is not recommended for ALS patients. It has never gone beyond testing in mice – – no human testing or results. It has been circulating in the ALS community for a number of years (since 2012); still no valid published results.

      Dr. Bedlack, through his ALS Untangled site, published an evaluation of this alternative protocol with the above conclusions. The website sells “hope,” supplements and unproven advice.

      Here is his evaluation: https://www.tandfonline.com/doi/pdf/10.3109/21678421.2013.788405

       

    • #16054

      I am not recommending anything but a quick check shows that actually there are two scientific publications specifically about the DP and 22 other that cite one of those publications. And none seems to say that DP is without merit.

      In 2017:
      Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential.
      Lavado A, Guo X, Smith AS, Akanda N, Martin C, Cai Y, Elbrecht D, Tran M, Bryant JP, Colon A, Long CJ, Lambert S, Morgan D, Hickman JJ.
      https://pubmed.ncbi.nlm.nih.gov/30637316/

      Let’s cite a few sentences:
      ” In this study, glutamate exposure to human motoneurons was investigated and found not to significantly affect cell viability or electrophysiological properties. However, varicosities were observed in axons suggestive of transport impairment that was dose dependent for glutamate exposure. Surprisingly, a subset of the components of the DP eliminated these varicosities.”

      Nobody cited this article, so it reflects no interest in the scientific community (most ALS untangled reviews are in the same situation).

      In 2014:
      Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model.
      Ari C, Poff AM, Held HE, Landon CS, Goldhagen CR, Mavromates N, D’Agostino DP.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111621/

      22 scientific articles cited this last article.

      One of those that cited this article in 2019 says
      Studies using substances that provide additional energy such as caprylic triglyceride, ketogenic diet, triheptanoin, and the Deanna Protocol,a combination of metabolic supplements including medium chain tri-glycerides and arginineα-ketoglutarate, were shown to improve motor symptoms and protect loss of motor neurons in ALS animal models.
      Their conclusion is:
      In conclusion, we demonstrated impairments in the pentosephosphate and glycolytic pathways in hSOD1G93Amice CNS tissues at the onset of disease, which are expected to lead increased oxidative stress. Also, this will impair ATP generation and contribute to subsequent energy deficit in ALS. These findings emphasize the role of metabolic dysfunction in the pathogenesis and progression of ALS and the need to correct metabolic abnormalities and protection against oxidative stress to improve outcomes

      It is this article:https://pubmed.ncbi.nlm.nih.gov/30685842/

      Again I do not recommend anything. But what is surprising is that there were more than 700 clinical trials about ALS, some with dubious substances (like epileptic drugs) and other trying repetitively but unsuccessful the same drug like memantine (5 times). DP looks not so weird in comparison, why DP has not attracted enough interest in any ALS organization to fund a clinical trial?

      Jean-Pierre

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