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New way identified to track severity and progression of ALS
Came across a really interesting study and would love to hear your thoughts. The study, “A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS,” was published in Neurology.
| By Adrianna MacPherson
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2 Replies
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Interesting abstract. The researchers did find a correlation with ALSFRS and the amount of white matter degeneration, which could help predict speed of the ALS progression. But the study was very small and relatively brief – 66 PALS and 43 healthy controls over three clinic visits (the abstract did not indicate actual time span.) A much larger and time-extended study might help in being able to use data to predict and pinpoint progression.
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An additional URL on this topic is:
Rich
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Saw another article on the corticospinal tract (CST) that explained that other disorders can do this also, so as this is a step forward, it is not a conclusive diagnostic tool. Wish it were, but it does limit the number of possibilities that need to be ruled out. My MRI did show white matter issues in the CST. Waiting now for further development from my Neuro. They are pushing me to start Radicava now as well so this is persuasive. Been through so many tests, I have become numb now.
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