[DAVID]

Hi

I thought of providing quick feedbacks on Ashwagandha (Withanoside IV compound only) and Pomegranade seed oil supplements that my Dad has been taking for 15 months and 8 months respectively (on top of CQ10, TOCO and Ginkgo).
Despite daily intakes of those supplements, my Dad unfortunately kept experiencing some steady decline in upper & lower limb, as well as speech. That is not to say such supplementation is useless, as I have no idea of what would have happened without it. But I thought it would be good to share with you that, sadly, nothing groundbreaking happened in my Dad’s case. We do not plan to stop supplementation, though, and keep investigating other candidates.

For the context, my Dad was diagnosed with ALS in 2017, the most noticeable symptom being dysarthria which started in 2015. Difficult to say if this was a real bulbar onset, given that he did not seem to have experienced the “standard” phenotype and rapid progression usually associated to it. Which make me believe that earlier light limb symptoms may have gone unnoticed (I wish so much that bio-markers will become a reality).

[DAVID]

Hi Walter

Do you believe high doses B12 had an impact ?
My Dad had injections last year. Unsure if it/how much it helped

[DAVID]

Exactly – it is unfortunate no clinical trials to confirm those findings were funded so far though.

[DAVID]

Hi Dagmar

I was referring to the fact that, in some experiments, Withaferin A is shown to reduce neuro-inflammation, as explained in the specific context of ALS at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322065/.

[DAVID]

Thank you Jean-Pierre !

[DAVID]

Hi Giselle, Owen,

I wished I replied earlier but I somehow did not receive ALS forum notifications…

@Giselle : thank you for the pointer, never heard of it but will definetly look further.

@Owen : you are totally right, most raw ingredients are the same I believe. Before I found out about Ethnodyne, I was indeed considering taking a shot at Protandim. Considering I was in France, I managed to grab more info about Ethnodyne from their research team, so I decided to go for it. I believe that one difference between Protandim and Ethnodyne Neuro though, is that the Ashwaganda active compound in use in Protandim is Withaferin A whereas the active compound in use in Ethnodyne Neuro are essentially Withanosides. Both are believed to have neuro-protective effects though and I am not sure to have a proper understanding of the key differences between the two to share them here, but you can make your own call by googling the related & significant litterature.

[DAVID]

Hi Giselle

My dad takes Ethnodyne Neuro, sold on ethnodyne.com. It is backed by research from a team of French scientists from CNRS (French national research center). They use a bioconversion extraction process meant to enhance their active components. My dad takes two doses a day. Note that it is a combination of ashwagandha root extracts As well as two other well known Ayurvedic plants. But ashwagandha has the highest concentration (800mg per two doses).

[DAVID]

Hi Jean-Pierre

Thank you for your work ! Do you publish a french version ?

 

[DAVID]

Hi Mikki

I realized I had missed you reply : thank you for this. I will forwarded it on to my dad.
Does it still hold btw ?

 

[DAVID]

Thank you for this, Dagmar. I will look into the article.

[DAVID]

Hello

Are the components of RCH-4 advertised anywhere ? Does anyone know whether any lab have or has plans to conduct such investigation ?

Thank you