@djshuey
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David Shuey replied to the topic New study shows ALS/MND damage to nerve cells can be repaired by improving the energy levels in mitochondria in the forum Research Topics 1 year, 10 months ago
FYI – Several excellent threads at the ALS-TDI Forums (https://www.als.net/forum/) discuss the link between mitochondrial health and ALS pathologies and suggest a number of potential therapeutic strategies.
The most comprehensive is clearly the discussion started back in 2014 by an excellent contributor Barbarawanda titled – Quality control of…[Read more]
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Kathryn F. Kennedy and
David Shuey are now friends 2 years, 6 months ago -
Dagmar Munn and
David Shuey are now friends 3 years, 8 months ago -
Amanda and
David Shuey are now friends 3 years, 8 months ago -
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David Shuey posted a new activity comment 3 years, 8 months ago
Hi Julie, my name is Dave and my wife has been battling ALS for almost 11 years. She does not have the C9 allele, but I do know a little about this form of the disease. There is very promising news from a group at the Mayo Clinic collaborating with Ionis/Biogen using ASO technology. Are you aware of the ongoing clinical trials?
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David Shuey posted a new activity comment 3 years, 8 months ago
That the tandem hexamer C9 repeats make nearly perfect DNA binding sites for the transcription factor Sp1. 9/10 consensus match.
Dont know that anyone has even thought of this, or its potential implications to ALS.
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David Shuey changed their profile picture 3 years, 8 months ago
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David Shuey started the topic A novel theory of the C9orf72 hexamer repeat neurotoxicity. in the forum Research Topics 3 years, 8 months ago
I have an idea (4 pg proposal) that I’m pretty sure is correct and may be worth investigating, but do not know who to forward it to. Anybody have any ideas?
Thx ~ Dave
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If you don’t mind me asking, what does this four-page proposal state?
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David Shuey became a registered member 3 years, 8 months ago
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Hi David, my name is Michael Morale. I’m the Director of Multichannel Content for ALS News Today. I wanted to welcome you and thank you for joining our forum. We hope that you will take time to go through all of the open conversations that are actively in progress, and feel free to join in. We strive to bring you the information that you need to m…[Read more]
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That the tandem hexamer C9 repeats make nearly perfect DNA binding sites for the transcription factor Sp1. 9/10 consensus match.
Dont know that anyone has even thought of this, or its potential implications to ALS.
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Hello David, my name is Dagmar. I’m one of the forum co-moderators and wanted to welcome you and thank you for joining our forum! We hope you will take the time to go through all the open conversations that are in progress and feel free to join in. If you have any questions or concerns or even suggestions, just let us know, and we will do our b…[Read more]
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Hello David and welcome to the ALS forum. I am Amanda, one of the co-moderators of the ALS forum. Have a look at the forum and discussions. You are welcomed post comments, ask questions and provide feedback. We are here to provide support and information. Please let us know if we can do anything to be helpful.
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I have c9orf72 and would like to meet others that have this gene mutation
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Hi Julie, my name is Dave and my wife has been battling ALS for almost 11 years. She does not have the C9 allele, but I do know a little about this form of the disease. There is very promising news from a group at the Mayo Clinic collaborating with Ionis/Biogen using ASO technology. Are you aware of the ongoing clinical trials?
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I have tried to get in several trials but my breathing capacity is only 36%
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