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	<title>ALS News Today Forums | Klaus68 | Activity</title>
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				<title>Klaus68 replied to the discussion Is non-familial ALS a genetic disease? in the forum Diagnosis​ ​Information​ ​and​ ​General​ ​Questions</title>
				<link>https://alsnewstoday.com/forums/forums/topic/is-non-familial-als-a-genetic-disease/#post-23324</link>
				<pubDate>Thu, 05 Jan 2023 21:42:38 -0600</pubDate>

									<content:encoded><![CDATA[<p class = "activity-discussion-title-wrap"><a href="https://alsnewstoday.com/forums/forums/topic/is-non-familial-als-a-genetic-disease/#post-23324"><span class="bb-reply-lable">Reply to</span> Is non-familial ALS a genetic disease?</a></p> <div class="bb-content-inr-wrap"><p>Michael, difficult to answer with a clear yes or no.  In familiar ALS we have the genes e.g  C9orf72, FUS and SOD1 with clear causalities in ALS cause by damaging motor neurons (MN) mostly triggering the mislocation of the hallmark ALS protein TDP-43 from the nucleus to cytosol and generating TDP-43 deposits.  Since TDP is regulating its gene&hellip;<span class="activity-read-more" id="activity-read-more-18058"><a href="https://alsnewstoday.com/forums/forums/topic/is-non-familial-als-a-genetic-disease/#post-23324" rel="nofollow"> Read more</a></span></p>
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				<title>Klaus68 replied to the discussion Relyvrio in the forum Diagnosis​ ​Information​ ​and​ ​General​ ​Questions</title>
				<link>https://alsnewstoday.com/forums/forums/topic/relyvrio/#post-23315</link>
				<pubDate>Thu, 05 Jan 2023 20:30:01 -0600</pubDate>

									<content:encoded><![CDATA[<p class = "activity-discussion-title-wrap"><a href="https://alsnewstoday.com/forums/forums/topic/relyvrio/#post-23315"><span class="bb-reply-lable">Reply to</span> Relyvrio</a></p> <div class="bb-content-inr-wrap"><p>Very good point about the antiacids. Aluminium and magnesium salts of phenylbutyrate might be very insoluble. They often are.<br />
Suzanne, are you taking any medication for your lack of gallbladder. usually this is the case. It might make sense to discuss with your PCP. Eventually you can reduce this medication now and see if the diarrhea gets&hellip;<span class="activity-read-more" id="activity-read-more-18051"><a href="https://alsnewstoday.com/forums/forums/topic/relyvrio/#post-23315" rel="nofollow"> Read more</a></span></p>
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				<title>Klaus68 replied to the discussion Relyvrio in the forum Diagnosis​ ​Information​ ​and​ ​General​ ​Questions</title>
				<link>https://alsnewstoday.com/forums/forums/topic/relyvrio/#post-23308</link>
				<pubDate>Wed, 04 Jan 2023 17:02:37 -0600</pubDate>

									<content:encoded><![CDATA[<p class = "activity-discussion-title-wrap"><a href="https://alsnewstoday.com/forums/forums/topic/relyvrio/#post-23308"><span class="bb-reply-lable">Reply to</span> Relyvrio</a></p> <div class="bb-content-inr-wrap"><p>I have been on Relyvrio (BTW terrible name choice IMO) since about a month. (I am also on Radicava oral and Riluzole since my diagnosis in July 2022)) . I have not noticed any side effect from Relyvrio. I do combat the truly terrible taste with chasing it with a small glass of LEAP 2befit (orange) in the evening and in the morning with&hellip;<span class="activity-read-more" id="activity-read-more-18034"><a href="https://alsnewstoday.com/forums/forums/topic/relyvrio/#post-23308" rel="nofollow"> Read more</a></span></p>
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				<title>Klaus68 became a registered member</title>
				<link>https://alsnewstoday.com/forums/activity/p/16974/</link>
				<pubDate>Tue, 23 Aug 2022 00:29:17 -0500</pubDate>

				
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				<title>Klaus68 updated their profile</title>
				<link>https://alsnewstoday.com/forums/activity/p/16972/</link>
				<pubDate>Mon, 22 Aug 2022 15:05:20 -0500</pubDate>

				
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