What are the early signs of ALS?

The earliest signs of amyotrophic lateral sclerosis (ALS) vary from patient to patient, and depend on the region of the body that is first affected. For the vast majority of patients, in which limbs are first affected, early symptoms include difficulty grabbing objects or writing, and trouble with walking and balance. When the first muscles affected are located around the mouth and throat, initial symptoms include problems speaking or swallowing.