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In every person, bloating may be caused by a digestion problem: If your gastrointestinal tract has difficulties to process food containing carbohydrates, then bacteria that colonize the GI tract will process them, and unfortunately they produce gas in doing so .
A personal hypothesis (I am not a doctor): May be for pALS using a feeding tube some…[Read more]
I will not comment specifically on Berberine and TDP-43, but more about neurotoxicity.
The most simple explanation has been given by Paracelcius: <strong class=”_12FoOEddL7j_RgMQN0SNeU”>It is the dose that differentiates a poison from a remedy.”
For example people inject a dangerous poison in their skin (Botox) to get rid of…[Read more]
I do not know this platform but it seems under Merit Cudkowicz supervision.
As I read daily new research on ALS, I can assure you that she is someone who did a great contribution to the field.
She is probably one the 10 best US scientists in the area of ALS.
I am not recommending anything but a quick check shows that actually there are two scientific publications specifically about the DP and 22 other that cite one of those publications. And none seems to say that DP is without merit.
Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential.
Lavado A,…[Read more]
Thanks David, I really appreciate.
There is a French version, it is also available as an ebook :
Initially I planned to publish an updated version in October. But so far 2020 had not been very prolific on the ALS research front. I look forward at the results from the clinical studies of Arimoclomol and…[Read more]
No one knows the etiology of ALS. Some scientists believe that the blood supply may be an important factor. This is an interesting hypothesis because it would group many neurodegenerative diseases under a common umbrella. Depending on the area of the brain that would be affected, this would cause ALS (motor cortex) or Parkinson’s (midbrain),…[Read more]
I agree with you Kasper, particularly about the risk that no insurer will pay so much.
This reminds me about Glybera, it was a gene therapy treatment designed to reverse lipoprotein lipase deficiency (LPLD), a rare inherited disorder which can cause severe pancreatitis.
Its cost was $1…[Read more]
Misfolded and mislocated inclusions of the protein TDP-43 are found in most cases of ALS, but also at a lesser degree in FTD, Alzheimer and Parkinson.
While it was suspected since a long time that those inclusions have something in common with stress granules which are somewhat similar vesicles created by cells that are enduring critical stress,…[Read more]
I am not a doctor, but I think that Nurown is the fruit of a line of research which is valid: How to administrate neurotrophic factors were they could be useful.
Nurown is certainly not the final cut in this line of research, I expect new therapies to be more effective and/or easier to administrate. Intrathecal administration is not fun at all,…[Read more]
“Did the researchers look at if the high LDL levels were present prior to diagnosis?”
To try to answer this question, the scientists did not check people with ALS directly. What the scientists did in this study is comparing large banks of genomes expression (GWAS) one obtained from healthy people and the other from people being…[Read more]
For anyone studying research against neurodegenerative diseases, it is striking to note the large number of studies which each claim to have identified a key element different from the others, and which would be a causative factor of the disease. In addition, many studies are contradictory.
In epidemiology, Mendelian randomization is a method…[Read more]
Scientists from UK and Taiwan have developed a modeling platform at the cellular level, which summarizes the key aspects of sporadic ALS and demonstrates both an initial neuroprotective role for astrocytes and the cell-type specific toxic effect of TDP-43 oligomers.
In addition, these scientists demonstrated that highly purified r…[Read more]
There are two hypotheses about the starting point of ALS in the anatomy. One hypothesis states that it starts in the motor cortex where reside upper neurons bodies, while the other hypothesis tells it starts at the other end of the motor pathway in the neuromuscular junction or even in the muscular fibers that the lower motor neurons axon…[Read more]
In the article about Gemin3, there is an important mistake in a copy/past from the original article in Nature reports.
What is written in the ALSNewsToday article is that “Problems with the TPD-43 protein have been identified in around 5% of familial ALS, and fewer than 1% of sporadic ALS cases.”
This is very false as on contrary TDP-43…[Read more]
I am a great fan of scientists like prof. Ludolph.
Scientists from his team, in South-West of Germany, have investigated the associations of serum concentration of insulin-like growth factor 1 (IGF1) with prognosis of ALS in their region ALS registry in a case-control and cohort study, respectively.
Their study showed a clear association of…[Read more]
I think we have a limited vocabulary to describe this new situation so it is difficult to express our thoughts.
In my opinion Dagmar is right to talk about little exercises like learning new tricks to move the body and adapting to the new ALS life. What is probably important is the complexity of the activity and not its energy consumption.
In my opinion, for now Nurown worth the pain inherent to its administration and it should be administrated every few months. Arimoclomol is probably something more easier to prescribe to patients (and hopefully less costly) as it does not mandate a special medical procedure and has a clear and understandable mechanism.
Apart from that there are…[Read more]
I am sorry for you and your family.
1) There are some research on FUS gene mutations. For example look at the following link, those scientists are in Belgium, so not far from the Netherlands.
2) I am not sure there is a better support in US than in Western Europe (for example there are many great people in Ulm).
3) see…[Read more]
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