[Sara]

Hi Dagmar, thank you for your help in framing my questions.

1. TUDCA: yes, there is some data that PALS lose function more slowly with this supplement vs. PALS taking placebo. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024041/  It is available OTC. I would suspect that some PALS on this forum are taking this, and I’m hoping to get a recommendation on brand.

1. Methylcobalamin is a type of B12 (most OTC is cyanocobalamin). In my (quick) perusing, it seems that IM is the only studied route. https://jnnp.bmj.com/content/90/4/451

I am curious is anyone is aware of any data supporting oral administration. I can’t find any, so it seems one would not want to take oral B12 supplements for ALS (of course there are other reasons to take B12)

Thank you very much!

 

 

[Sara]

Is anyone taking oral methylcobalamin? It seems that the research is really only around IM delivery. Is there any utility to oral methylcobalamin? And if so, what dose?

 

Also, as to TUDCA, which seems quite interesting, can anyone recommend a brand? I feel quite in the wilderness when it comes to supplements and I do worry about the quality/contaminations.

 

THANK YOU!