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Neudexta – for speech and swallowing benefits
Hi everyone,
I wanted to check in on the drug Neudexta. Has anyone experienced any benefits for swallowing or speech? I know Dr. Richard Bedlack has also recommended this drug for these symptoms. Based on feedback, I wanted to see if I should start this medication or not. Thank you and hope all is as well as it can be 🙂
Best,
NJ Guy
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10 Replies
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Njguy — the information about Neudexta is that it is the only FDA-approved prescription medication used to treat Pseudobulbar Affect (PBA). PBA is a neurological condition characterized by involuntary, sudden, and frequent episodes of crying or laughing that don’t match how a person actually feels. Nowhere can I find that it treats swallowing issues or is used to help speech.
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Hello Dagmar,
I know that this is used for PBA. In New Jersey, I have seen many ALS patients taking Neudexta, as per Dr. Bedlack if you follow his lectures and seminar videos. Maybe in a month or so I may decide to start. It also comes in a liquid form as supplied by compounding pharmacies.
Best,
NJGuy
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Hi , I’ve been taking Nudexta for several months. My voice was starting to change. I’m limb onset with symptoms in 23 and diagnosed in 25. Voice seems to have plateaued . No issues swallowing as of yet. No medication side effects. I say go for it and if it helps, yeah, if not stop, here’s a link to a study completed by Dr.James Wymer in 2022. He’s a great MD. Practices at university of Florida in Gainesville in addition to being ALS medical director at the VA Medical Center in Gainesville as well. You may already be familiar with the article.
Best of luck ,
Nancy
https://www.neurologylive.com/view/ability-nuedexta-improve-bulbar-function-swallowing-speech-als
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This is an interesting study. Although it was conducted on only 28 patients and lasted only 4 weeks. In addition, the patients only had to report “better” or “not better.” (Self-reporting is good, but not scientific)
Furthermore, Neudexta was initially approved to treat ALS-related emotional outbursts — so, we should be cautious about recommending it to other forum members. -
Thanks Dagmar for your comment, understand we shouldn’t recommend treatment, it is between the pals and MD to discuss treatment options Meant to only share my experience and research I had found. It is recommended in the article for further research consisting of administering a placebo along with Nudexta.
Nancy
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I never heard of it. Maybe because I am Bulber onset. I do not know
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I want to take this medicine. But in our country, if you’re not willing, can we have more doctors? I am willing to offer double the price.
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I’d like to take it too. Diagnosed with Upper Motor Neuron Dominant ALS 1.5 years ago. Still able to talk and swallow but not normal.
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DrBarb, I began having voice and swallowing problems about 10 yrs. ago. Treatments like Nuedexta weren’t available then. Rather than give up, I decided to accept my new voice and modify what I ate/drank. Maybe one of these two posts of mine will be of help to you.
https://alsandwellness.blogspot.com/2024/10/im-still-talking-and-sharing-strategies.html
https://alsnewstoday.com/columns/als-hard-act-swallow-tips/
alsandwellness.blogspot.com
I’m still talking! And sharing strategies that help my ALS speech
ALS patient Dagmar Munn share the various strategies she uses to help her ALS speech
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Hi all,
If you are in New Jersey, Hopewell Pharmacy (or any other compounding pharmacy) can offer this in liquid or pill form. You would need a prescription from your neurologist. According to Dr. Bedlack, this medicine does help and it works in about 2-3 weeks. Please watch the presentation by Dr. Bedlack published on Youtube in December 2025.
Wish you all the best,
NJGuy
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