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Supplement research
Hi all- I’m a new member. I posted this in reply to another comment, but thought I’d start a new thread here under research as well. My wife was diagnosed with ALS recently, and I have been conducting research in a number of areas to try and wrap my head around the massive amount of information on ALS. One area I was looking into was supplements, and whether or not there is anything promising in this area. Below is a dump of research I’ve done on supplements. I’d be interested in hearing from people here 1) if anything on this list has been recommended to you by an ALS-focused neurologist, 2) if anyone has any personal experience with anything on this list and could comment on perceived benefits and side effects, and 3) if anyone has guidance from doctors or research studies on dosing levels. Thanks!
<u>Vitamins and supplements</u>
- Good overall summary: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712627/
- Good overall summary of metabolic treatments: https://www.frontiersin.org/articles/10.3389/fnins.2016.00611/full
- Big list of ALS supplements: https://alstuttu.org/wiki/index.php?title=Information_on_nutritional_supplements_people_with_ALS_have_been_taking
- Human studies with promising results:
- Vitamin D & E: https://alsworldwide.org/care-and-support/article/supplements-and-vitamins
- Methylcobalamin (Vitamin B12) – high dose of 25-50mg: http://informahealthcare.com/doi/pdfplus/10.3109/21678421.2015.1070574
- L-carnitine: https://www.ncbi.nlm.nih.gov/pubmed/23421600
- L-Serine: https://brainchemistrylabs.org/lserine
- Tauroursodeoxycholic acid (TUDCA): https://alsnewstoday.com/tudca-tauroursodeoxycholic-acid/
- Mouse models with promising results
- Ginseng: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659610/
- Extract of ginkgo biloba (EGb761): https://link.springer.com/article/10.1385/JMN:17:1:89
- Catechin in green tea (Epigallocatechin gallate): https://www.ncbi.nlm.nih.gov/pubmed/16356650; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585739/
- Alpha-Lipoic acid – specifically R(+)Alpha lipoic acid: https://www.ncbi.nlm.nih.gov/pubmed/29842900
- Nicotinamide mononucleotide (NMN): https://alsnewstoday.com/2018/01/19/study-shows-symptoms-of-mice-with-als-improve-after-they-are-treated-with-enzyme/
- Ashwagandha (SOD 1 variant only): https://www.ncbi.nlm.nih.gov/pubmed/30134145
- Deanna protocol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111621/; http://informahealthcare.com/doi/pdf/10.3109/21678421.2013.788405
- Cannabinoids: https://www.researchgate.net/publication/329447341_Effects_of_cannabinoids_in_Amyotrophic_Lateral_Sclerosis_ALS_murine_models_A_systematic_review_and_meta-analysis
- Mixed (but not necessarily negative) results
- Protandim – potentially sketchy but may have some promise: http://www.tandfonline.com/doi/pdf/10.3109/21678421.2015.1088707
- Theracurcumin – oral: https://www.tandfonline.com/doi/pdf/10.1080/21678421.2018.1440738?needAccess=true
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