Patient-derived Cell Model for Use in ALS Research Wins International 3Rs Prize

A model of motor neuron disease based on patient-derived stem cells won the 2018 International 3Rs Prize for its potential to lessen or replace the use of animals as models in amyotrophic lateral sclerosis (ALS) research. The prize, given by the National Center for the 3Rs (NC3Rs) and sponsored by …

Amylyx has completed patient recruitment for the Phase 2 clinical trial CENTAUR, which addresses the safety and effectiveness of AMX0035 as an oral treatment for amyotrophic lateral sclerosis (ALS). In 2017, Amylyx launched…

“I think, therefore I am.” I have long been fascinated by that argument of philosopher Rene Descartes. Similarly, over a millennium earlier, St. Augustine wrote, “I make mistakes, therefore I am.” Both suggest that cognition — self-awareness in Descartes’ case, knowing right from wrong per St. Augustine —…

Several species of bacteria and fungi were found living in the central nervous system (CNS) of patients with amyotrophic lateral sclerosis (ALS) that could potentially be related to the development of the disease, a study reports. However, according to the researchers, more studies are still needed to confirm if…

Growing up in Iowa, I knew that silos were beneficial for farmers who used them to store grain and corn. When I entered the workforce, silos were a negative thing. It was a term used to describe how some departments or managers don’t share information with other departments…

A specific type of supporting cells called Schwann cells protect against nerve degeneration induced by the blood-clotting protein thrombin, according to new research in mice. Researchers say the findings could have implications for treatment development in amyotrophic lateral sclerosis (ALS), multiple sclerosis, and Alzheimer’s. The study, “…

Biochemist Dorothee Dormann, PhD, at the Ludwig Maximilians University, in Munich, was awarded the 2019 Paul Ehrlich and Ludwig Darmstaedter Prize for Young Researchers for her groundbreaking work showing that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share common underlying processes that drive disease development.

Higher levels of apathy — particularly its behavioral symptoms — in people with amyotrophic lateral sclerosis (ALS) are associated with a degree of greater burden for caregivers, according to a new study. The research, “The burden of apathy for caregivers of patients with amyotrophic lateral sclerosis,”…

Madeline Collin, a 24-year-old activist with Gaucher disease, worries that patients like her will suffer deeply if Britain leaves the European Union (EU), as scheduled, at the end of this month. Collin is an expert on the subject. For her University of Bath dissertation, she analyzed Brexit’s long-term…

A magnetic resonance imaging (MRI) marker may facilitate amyotrophic lateral sclerosis (ALS) patients’ diagnosis and disease monitoring, a study finds. The study, “Is the Hypointensity in Motor Cortex the Hallmark of Amyotrophic Lateral Sclerosis?,” was published in the Canadian Journal of Neurological Sciences. ALS is a progressive neurological…