Approved Treatments for ALS

Exservan

Exservan (riluzole oral film) uses Aquestive Therapeutics’ PharmFilm technology. It’s an orange film containing a 50 mg riluzole dose that is taken twice a day by placing it on the tongue. It dissolves automatically and requires no water. The active ingredient in Exservan is also available as oral tablets (Rilutek) and as an oral suspension (Tiglutik).

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Radicava

Radicava (edaravone) is the first treatment for ALS that the U.S. Food and Drug Administration approved in more than 20 years. The therapy is designed to slow the decline of  physical function decline in people with ALS. The therapy also has been approved in Canada, where it is available under a number of different medication plans.

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Rilutek

Rilutek (riluzole) was the first treatment approved by the U.S. Food and Drug Administration to treat ALS in 1995. It is an oral formulation that acts to slow the progression of ALS symptoms and prolong survival. The exact mechanism by which Rilutek treats ALS is unknown. However, it is thought that the medicine blocks the release of glutamate from nerve cells.

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Tiglutik

Tiglutik (riluzole oral suspension) was approved by the U.S. Food and Drug Administration in September 2018. It is a liquid oral formulation of riluzole. Because ALS patients have difficulties swallowing, the administration of tablets can be difficult. Tiglutik is administered with an oral dosing syringe, which is more comfortable for patients.

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Symptomatic Treatments

There are also a number of therapies available that can help to treat the symptoms of ALS. As the disease can progress differently in each individual patient, the symptomatic therapies a patient is prescribed should be tailored to their needs. These therapies can help treat muscle symptoms, excessive saliva production, pseudobulbar affect, among a range of other issues. Learn more about some of these therapies at the links below.

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Your ALS Community

Visit the ALS News Today forums to connect with others in the ALS community. These forums are designed for patients, caregivers, and medical professionals to discuss issues, ask questions, and share experiences.

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