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November 16, 2018November 16, 2018

ALS-causative Mutations Directly Affect Sensory Nerves’ Growth and Stress Response, Preclinical Study Shows

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Sensory nerves carrying mutations in the TDP-43 or SOD1 genes — associated with the development of amyotrophic lateral sclerosis (ALS) — show impaired growth and stress responses, according to ... Read more

November 15, 2018November 15, 2018

Molecular Pathway Seen as ‘Intimate Tie’ Between ALS and Spinal Muscular Atrophy

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Mutations that affect a particular molecular pathway essential to protein production further support reports of a link between amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The study detailing ... Read more

November 14, 2018

Gene Therapy That Lowered SOD1 Protein in Primates Could Be Effective in ALS, Study Suggests

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A gene therapy effectively and safely lowered the production of a key amyotrophic lateral sclerosis (ALS) protein called superoxide dismutase 1 (SOD1) in primates, according to a new study. ... Read more

November 13, 2018November 13, 2018

Spinal Fluid and Blood Proteins May Diagnose and Predict Outcomes in ALS, Study Finds

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Specific proteins analyzed in cerebral spinal fluid and blood samples may help to diagnose amyotrophic lateral sclerosis (ALS) and predict patient outcomes, researchers report. Cerebral spinal fluid (CFS) protein ... Read more

November 12, 2018November 12, 2018

Prevalence of Motor Nerve Diseases, Including ALS, on Rise as Population Ages

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The prevalence of motor nerve diseases — including amyotrophic lateral sclerosis (ALS) — is on the rise worldwide, mostly because of an aging population. The disease burden is greatest ... Read more

November 9, 2018November 9, 2018

Teens and Young Adults Living with ALS Invited to Speak Out via Artist Creations in ‘Also Us’ Program

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To bring attention to the plight of teens touched by amyotrophic lateral sclerosis (ALS), Mitsubishi Tanabe Pharma America (MTPA) is calling for artistic submissions from young people who have ... Read more

November 8, 2018November 8, 2018

SARM1 Inhibition Has Potential to Prevent Neurodegeneration in ALS, Other Diseases, Preclinical Results Suggest

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Inhibition of the SARM1 gene can prevent the degeneration of nerve cells in the central, ocular, and peripheral nervous system in mice, results from preclinical studies show. These findings provide ... Read more

November 7, 2018November 7, 2018

FUS Mutation Common to Familial ALS Impacts DNA Repair Pathways in Motor Neurons, Study Shows

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Mutations in a gene linked to familial amyotrophic lateral sclerosis (ALS), called FUS, affect the ability of motor nerve cells to repair damage to their DNA, a new study ... Read more

November 6, 2018November 6, 2018

Denali and Sanofi Partner to Advance Small Molecules That Might Treat ALS, Other Diseases

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Denali Therapeutics and Sanofi have joined efforts to develop small molecule inhibitors of the RIPK1 enzyme, a new class of potential therapeutic agents for a range of neurological and ... Read more

November 5, 2018November 5, 2018

Multiple Rare Mutations in Genes Linked to ALS Can Lead to Earlier Disease Onset, Study Reports

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People with multiple rare mutations in genes known to cause amyotrophic lateral sclerosis (ALS) are significantly more likely to develop this disease at younger ages, a study in Japanese ... Read more

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