Researchers identify Novel Muscle Biomarkers of Disease Progression in ALS

In a recent report published in the PLOS One journal entitled “Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and…

The ALS Association, the country’s premier organization committed to find a cure for ALS and improving the lives of those affected by this rare disease, has just announced the viral and recently relaunched ALS Ice Bucket Challenge has played an integral role in pushing the creation of a new drug development…

Three prominent health institutions have recently come together to form the country’s largest coordinated and comprehensive initiative against amyotrophic lateral sclerosis (ALS). Last week, Johns Hopkins University’s Robert Packard Center for ALS Research, Cedars-Sinai Medical Center’s Regenerative Medicine Institute and the Massachusetts General Hospital Neurological Clinical Research Institute officially launched a joint…

Dr. Christopher Donnelly, PhD, is the first recruit for the University of Pittsburgh Brain Institute’s new Live Like Lou Center for ALS Research. A neurobiologist who co-led a study investigating hexanucleotide repeat expansion (HRE) which scientists say is the most common cause of Amyotrophic Lateral Sclerosis (ALS) and…

Johns Hopkins University researchers have announced that they will present the latest results of a study that reveals increased levels of endothelin 1 (ET-1) in astrocytes in the brain, along with increased levels of ET-B binding protein (the protein that binds to the ET-1 receptor) are associated with amyotrophic lateral sclerosis (ALS) or Lou…

The launch of Answer ALS, the largest comprehensive research project to cure Amyotrophic Lateral Sclerosis (ALS) was announced in a press release by the Johns Hopkins University’s Robert Packard Center for ALS Research in Baltimore, MD, the Cedars-Sinai…

MediciNova, a biopharmaceutical company that creates and studies small molecule medications for the management of medical conditions with unmet medical needs, is currently undergoing research on ALS patients who use non-invasive ventilation and will be treated with MN-166, also called Ibudilast, as part of a study on the management of ALS. Currently there…

In a recent paper entitled “Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity” published in the Neuron journal, a team of researchers from the Salk Institute for Biological Sciences, La Jolla, CA and the University of Texas,…

Karyopharm Therapeutics Inc., a clinical-stage pharmaceutical company focused on the discovery and development of novel first-in-class drugs for the treatment of cancer and other major diseases, recently announced the evaluation of its SINE nuclear transport compound KPT-350 as a treatment for Amyotrophic Lateral Sclerosis (ALS). Results from preclinical studies will…

Almost 6 million Americans are living with some form of paralysis, including nearly 1.3 million who have suffered spinal cord injuries. However, a team of University of California at Los Angeles (UCLA) scientists reports this week that a 39-year-old man who has been completely paralyzed for four years was…