ALS medication AMX0114 shows safety, moves to 2nd trial group

AMX0114, being developed as an amyotrophic lateral sclerosis (ALS) medication, has been well tolerated in early clinical testing, and a second group of patients will now test a higher dose of the experimental treatment. The first group of 12 participants enrolled in the Phase 1 LUMINA clinical trial…

I had a bad cold last week and am still recovering from it. Apart from concern over my husband, Todd, catching it, because he has ALS, the hardest part was trying to keep up with his caregiving when I was fatigued and needed to rest. Something surprised me, though:…

Neurosense Therapeutics is gearing up to submit an application to Health Canada for approval of PrimeC to treat amyotrophic lateral sclerosis (ALS). The company said it had a “productive discussion” with Health Canada, during which the agency confirmed that Neurosense’s proposed next steps align with its expectations. A…

Living with ALS certainly comes with many frustrations. For me, the one that challenges me most is a symptom I can’t hide: slowness. My body simply needs more time to move, eat, and speak than everyone else around me. In a world obsessed with speed — from 10-second commercials…

Actor Eric Dane is teaming up with Target ALS on a campaign to raise $500,000 by Dec. 31 to advance research on amyotrophic lateral sclerosis (ALS). Dane, who was diagnosed with ALS last year, has become a strong advocate for research. He portrayed a character with…

An ALS Association grant totaling nearly $1 million will support a clinical trial testing Pasithea Therapeutics‘ PAS-004 in people with amyotrophic lateral sclerosis (ALS). Funding for the Phase 1 trial is provided by the ALS Association’s Hoffman ALS Clinical Trial Awards Program, an initiative designed to support early…

Clene is planning to submit an application to the U.S. Food and Drug Administration (FDA) in early 2026 requesting accelerated approval of its oral therapy CNM-Au8 for treating amyotrophic lateral sclerosis (ALS). The company’s announcement follows new, positive data — from FDA-requested analyses — showing that CNM-Au8…

My husband, Todd, was asked about his health over the Thanksgiving weekend as we caught up with some old friends. He and I explained that his breathing has been declining recently, that ALS has taken most of his lung function, and he now has to eat with his…

A Phase 2 clinical trial to investigate Tiziana Life Sciences’ intranasal foralumab for the treatment of amyotrophic lateral sclerosis (ALS) has been accepted into the Healey ALS MyMatch program at Massachusetts General Hospital. The program, located at the Sean M. Healey & AMG Center for ALS, is a…

So what happens now? All of a sudden, I was on my own, left to navigate my world, which had changed forever. I was restless, not quite knowing what to do with myself or how to fill my time. I’d just spent the last two years fully focused on my…