Insitro and Bristol Myers Squibb have expanded their ongoing collaboration to develop new treatments for amyotrophic lateral sclerosis (ALS), adding two newly identified disease targets to their ongoing research effort. The two drug companies have been working together since 2020 to uncover biological changes driving ALS…

The first patient has been dosed in a small clinical trial in Australia that’s testing CTx1000, Celosia Therapeutics’ experimental gene therapy, in people with amyotrophic lateral sclerosis (ALS). The one-time treatment is designed to reduce toxic buildups of the TDP-43 protein, which are believed to contribute to nerve cell…

My husband, Todd, and I work on New York Times puzzles while we eat breakfast. I sit next to him and feed him bites of his breakfast while I eat, too. One puzzle we work on is the Spelling Bee, where we earn points by forming words from seven different…

ACI-19626, an experimental imaging agent developed by AC Immune, may safely detect abnormal clumps of the protein TDP-43 in the brain, a hallmark of amyotrophic lateral sclerosis (ALS) and other neurological conditions. That’s according to early data from a Phase 1 clinical trial (NCT06891716) evaluating the safety and…

“Be like a duck: calm on the surface, but always paddling like the dickens underneath.” That was an ongoing joke shared among my fellow hospital department managers during my working years. It’s a quote often attributed to actor Michael Caine, and it perfectly represented our mindset: putting on…

Early treatment with AL-S Pharma‘s infusion therapy AP-101 significantly extended survival and delayed the need for respiratory support in people with amyotrophic lateral sclerosis (ALS), compared with a six-month delay in starting therapy, new trial data show. The therapy candidate is being developed to target and clear…

The ALS Network and ALS United are inviting U.S. researchers to submit proposals for a new round of funding aimed at accelerating progress toward new treatments for amyotrophic lateral sclerosis (ALS). The funding is part of the expanding ALS Research Innovation Initiative. It’s intended to support “bold” and …

Several commonly used medications may be repurposed to extend survival in people with amyotrophic lateral sclerosis (ALS), according to an analysis of the electronic medical records of more than 11,000 U.S. veterans. Researchers found that certain classes of medications were associated with improved survival in ALS, including statins, which…

An analysis of how polarized light interacts with clumps of proteins in the eyes may help differentiate amyotrophic lateral sclerosis (ALS) from Alzheimer’s disease and related conditions, a new study shows. In experiments using post-mortem retinal samples — a light-sensitive layer at the back of the eye — researchers…