‘Hero’ Proteins Protect Cells from Toxic Clumps Underlying ALS, Other Neurodegenerative Diseases
Human cells produce a type of proteins, termed “Heroes,” that protect against the formation of toxic protein aggregates involved in…
Articles by Ana Pena, PhD
New Spinal Delivery Method Renders Stem Cell Therapy Safer, More Effective for ALS, Other Diseases, Early Study Suggests
A new spinal cell delivery method may reduce the risks and boost the effectiveness of stem cell therapy designed…
Single Injection of RNA Therapy Blocks Degeneration, Prevents Disease Progression in Mice Models of Familial ALS
A single spinal injection of an investigational RNA therapy blocked motor neuron degeneration and saved motor function in animal…
Reldesemtiv Effects Maintained When Used on Top of Rilutek or Radicava, New Trial Analysis Shows
Treatment with oral reldesemtiv appears to slow the deterioration of function — including breathing capacity and muscle strength —…
‘Jumping Genes’ Identified as Possible Cause of ALS, Linked to TDP-43 Protein Accumulation
A new study identified a group of sporadic amyotrophic lateral sclerosis (ALS) patients whose disease may arise from a…
Common Mutation in IL6R Gene May Mark More Severe and Faster Progressing ALS, Study Says
People with amyotrophic lateral sclerosis with a common mutation in the interleukin 6 receptor (IL6R) gene appear likely to…
Mexiletine Reduces Frequency, Severity of Muscle Cramps in ALS, Trial Shows
Mexiletine, an oral medicine to treat irregular heartbeats, is safe and effective for reducing muscle cramps in patients with…
Reldesemtiv May Reduce Functional Decline in Fast Progressing ALS, New Analysis Suggests
Experimental treatment reldesemtiv appears to reduce functional deterioration in patients with fast progressing amyotrophic lateral sclerosis (ALS), a…
Energy Demands to Counter Gravity in Vertical Neurons May Lie at Origin of ALS, Study Proposes
Excessive energy demands to overcome gravity in nerve cells directed downward — such as those involved in the control of…
Motor Neurons in Familial ALS Have Mutation-Specific Alterations in Glutamate Signaling, Study Found
Stem cell-derived motor neurons from people with familial amyotrophic lateral sclerosis (ALS) have mutation-specific…