ALS Hallmark, Clumps of TDP-43 Protein, Appears to Protect Nerve Cells, Study Reports
In contrast to what is often assumed, new research suggests that clumps of the protein TDP-43 — a hallmark of…
Articles by José Lopes, PhD
FDA Publishes Guidance to Help in Developing New ALS Therapies
After gathering input from patients, researchers, and advocates, the U.S Food and Drug Administration (FDA) has released new guidance on…
Daiichi Sankyo Seeks Approval to Market Radicava in Brazil
Daiichi Sankyo is looking to market the amyotrophic lateral sclerosis (ALS) treatment Radicava (edaravone) in Brazil after…
Riluzole More Effective with Complementary Therapies Like Radicava, Study Suggests
The benefits of riluzole, an approved treatment for amyotrophic lateral sclerosis (ALS), is thought to partly lie in its…
Levosimendan May Bolster Lung Strength in ALS Patients, Phase 2 Trial Suggests
Daily use of levosimendan capsules appear to preserve respiratory strength in people with amyotrophic lateral sclerosis (ALS) while in…
Facial Nerve Atrophy Seen on High-resolution MRI Helps Diagnose ALS in Early Stages, Study Reports
Assessing the degree of atrophy, or shinkage, in facial nerves with a high-resolution imaging tool appears to provide an accurate…
Neurofilament Light Chain Levels Able Blood Marker of Likely ALS Progression, Study Finds
People with amyotrophic lateral sclerosis (ALS) have higher blood serum levels of neurofilament light chain (sNfL) than do healthy…
Orphazyme Partnership to Run Through Extension of Phase 3 Arimoclomol Study
Orphazyme announced that it and Worldwide Clinical Trials will continue their collaboration through the long-term extension of a Phase…
Changes in Lipid Levels and Metabolism in Spinal Cord Mirror ALS Progression, Early Study Suggests
Amyotrophic lateral sclerosis (ALS) progression is associated with higher levels of specific lipids in the spinal cord and changes in…
$3.1 Million Grant to Help Find Therapies Targeting Neuron Loss in ALS
A $3.1 million grant from the National Institute on Aging (NIA) is intended to help two scientists at…