Study Finds Differences in Cerebrospinal Fluid Dynamics in ALS
There are differences in the way the fluid around the brain and spinal cord moves in people with amyotrophic…
Articles by Marisa Wexler, MS
Editing of SOD1 Gene Slows ALS Progression in Mice, Study Finds
A gene editing technology based on CRISPR was able to slow the progression of amyotrophic lateral sclerosis in a…
Fish Model of ALS Links TDP-43 Protein Clumping to Motor Neuron Ills
A zebrafish model that reproduces key amyotrophic lateral sclerosis (ALS) symptoms and characteristics, including protein clumping, when exposed to…
Astrocytes in Nervous System Seen to Protect Motor Neurons from Toxicity of Clumps
Astrocytes — cells of the nervous system cell that provide support to neurons — were seen to help protect motor…
Monkeys on Neurotoxic Diet May Be New Animal Model for ALS Research
A neurotoxic amino acid called β-N-methylamino-L-alanine (BMAA) fed to vervet monkeys caused damage to the spinal cord similar to what…
C9ORF72 Mutations Disrupt Cellular RNA and Protein Processing, Study Finds
Mutations in the C9ORF72 gene, the most common cause of…
Gene Seen to Protect Motor Neurons May Serve as ALS and SMA Therapy, Study Suggests
The protein synaptotagmin 13 (SYT13) protected motor neurons from degeneration in cell and animal models of amyotrophic lateral…
ALS Telecare App Benefits Patients, Providers, Study Shows
People with amyotrophic lateral sclerosis (ALS) may benefit from at-home monitoring using an app, a study found. The study,…
Potential Protein Target for Antibody Therapy Identified in Early Study
Antibodies that target proteins wrongly expressed in the brain and driven by mutations in C9ORF72, a cause of amyotrophic…
Study Links Cognitive Impairment with Toxic Protein Clumps in ALS
Cognitive impairment in amyotrophic lateral sclerosis (ALS) may be linked to the buildup of the protein TDP-43 in…