Fish Model of ALS Links TDP-43 Protein Clumping to Motor Neuron Ills
A zebrafish model that reproduces key amyotrophic lateral sclerosis (ALS) symptoms and characteristics, including protein clumping, when exposed to…
Articles by Marisa Wexler, MS
Astrocytes in Nervous System Seen to Protect Motor Neurons from Toxicity of Clumps
Astrocytes — cells of the nervous system cell that provide support to neurons — were seen to help protect motor…
Monkeys on Neurotoxic Diet May Be New Animal Model for ALS Research
A neurotoxic amino acid called β-N-methylamino-L-alanine (BMAA) fed to vervet monkeys caused damage to the spinal cord similar to what…
C9ORF72 Mutations Disrupt Cellular RNA and Protein Processing, Study Finds
Mutations in the C9ORF72 gene, the most common cause of…
Gene Seen to Protect Motor Neurons May Serve as ALS and SMA Therapy, Study Suggests
The protein synaptotagmin 13 (SYT13) protected motor neurons from degeneration in cell and animal models of amyotrophic lateral…
ALS Telecare App Benefits Patients, Providers, Study Shows
People with amyotrophic lateral sclerosis (ALS) may benefit from at-home monitoring using an app, a study found. The study,…
Potential Protein Target for Antibody Therapy Identified in Early Study
Antibodies that target proteins wrongly expressed in the brain and driven by mutations in C9ORF72, a cause of amyotrophic…
Study Links Cognitive Impairment with Toxic Protein Clumps in ALS
Cognitive impairment in amyotrophic lateral sclerosis (ALS) may be linked to the buildup of the protein TDP-43 in…
ALS Research Ambassador Collaboration Enabled More Patient-centered Design of REFINE-ALS Trial
Including ALS Research Ambassadors — a group of amyotrophic lateral sclerosis (ALS) patients and their caregivers — in discussions about…
Insurance Data May Predict ALS, Research Shows
A machine-learning model based on insurance information from amyotrophic lateral sclerosis (ALS) patients may be able to speed diagnosis…