Stress-sensing Molecule May Be Potential Therapeutic Target in ALS
A small molecule called microRNA-182-5p (miR‐182‐5p) is involved in the detection of cell stress and in the survival of…
Articles by Marta Figueiredo, PhD
Cancer Immunotherapy Aldesleukin Shows Promise for ALS in Pivotal Trial
Low doses of Clinigen’s aldesleukin, an immunotherapy used in certain types of cancer, safely boosted the number and…
Lower Levels of MicroRNA in ALS Patients Linked to Nerve Cell Damage
People with amyotrophic lateral sclerosis (ALS) have significantly lower levels of a small molecule called microRNA-335-5p (miR-335-5p), which promotes…
Target ALS and ALS Association to Fund Research on TDP-43’s Potential as ALS Biomarker
Target ALS and The ALS Association will jointly fund two projects focused on the development of new tests to…
Collaboration Funds Experimental Therapy for Rare FUS-ALS
Eight patients will receive jacifusen, an experimental therapy for amyotrophic lateral sclerosis (ALS) caused by FUS gene mutations, under…
Preclinical Study Offers New Clues to the Link Between ALS and Type 2 Diabetes
The presence of autoantibodies against a calcium channel in people with amyotrophic lateral sclerosis (ALS) may explain the frequent development…
FDA Gives OK to HEALEY ALS Platform Trial Testing Zilucoplan, CNM-Au8, and Verdiperstat
The U.S. Food and Drug Administration (FDA) has authorized the evaluation of the first three candidate therapies for…
Mitochondrial ‘Suicide’ May Signal Start of Neurodegeneration in ALS, Mouse Study Suggests
A newly discovered self-destructive mechanism in mitochondria, the cells’ powerhouses, may be one of the first deficits leading to motor…
Top 10 ALS Stories of 2020
ALS News Today brought you daily coverage of key findings, treatment developments, clinical trials, and…
Orion Presents Data on How Levosimendan Works in ALS and Disease Biomarkers
Researchers with Orion Corporation presented new data on levosimendan‘s mechanism of action, and potential biomarkers of amyotrophic lateral…