Nasal Administration of Two Neuroprotective Proteins May Have ALS Application, Mouse Study Suggests
Nasal administration of two neuroprotective proteins, called Activin A and SerpinB2, reduced brain damage in a mouse model of stroke,…
Articles by Patricia Inácio, PhD
Decline in Coughing Strength May Signal Poor Outcomes in ALS Patients, Study Reports
A decline of 25 percent each year in cough peak flow, a test of cough strength and airway…
Large Databases Used by ALS Registry Ably Capture Disease Prevalence in US, Study Reports
Federal healthcare databases, especially Medicare, are a valuable resource in identifying cases of amyotrophic lateral sclerosis (ALS) in the U.S. population,…
Phase 3 Trial of Oral Levosimendan as Respiratory Treatment for ALS Recruiting in US, Europe and Australia
A new Phase 3 trial evaluating levosimendan (also known as ODM-109), an oral treatment by Orion for breathing problems in amyotrophic…
ALS May Have Negative Affect on Muscles Necessary for Chewing, Study Finds
Patients with amyotrophic lateral sclerosis (ALS) show alterations in the activity of their masticatory (jaw) muscles, impairing their ability to…
Prediction Model May Help Personalize Survival Prognosis in ALS Patients, Researchers Say
Researchers have developed a personalized, non-invasive model that uses a set of characteristics, easily obtained at diagnosis, to predict survival…
Phase 1/2a Trial Recruiting ALS Patients to Test AstroRx, Potential New Stem Cell Therapy
The biotech company Kadimastem is recruiting for a Phase 1/2a clinical trial to test the safety and effectiveness of its leading…
Higher Genetic Risk for ALS Linked to Poorer Verbal, Numerical Skills in Adults in UK Study
A high genetic risk for amyotrophic lateral sclerosis (ALS), assessed using so-called polygenic risk scores, was linked in a study…
Specially Engineered Neural Cells Delay Disease and Extend Life in ALS Animal Model
Transplanting engineered neural cells into the brain of an amyotrophic lateral sclerosis (ALS) animal model delayed disease progression and extended the…
Size of SOD1 Protein Aggregates in ALS Patients’ Brains Leads to Different Outcomes, Study Shows
Size matters when it comes to SOD1 protein aggregates found in the brains of patients with amyotrophic lateral sclerosis…