In a recent paper entitled “Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity” published in the Neuron journal, a team of researchers from the Salk Institute for Biological Sciences, La Jolla, CA and the University of Texas,…
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Karyopharm Therapeutics Inc., a clinical-stage pharmaceutical company focused on the discovery and development of novel first-in-class drugs for the treatment of cancer and other major diseases, recently announced the evaluation of its SINE nuclear transport compound KPT-350 as a treatment for Amyotrophic Lateral Sclerosis (ALS). Results from preclinical studies will…
Almost 6 million Americans are living with some form of paralysis, including nearly 1.3 million who have suffered spinal cord injuries. However, a team of University of California at Los Angeles (UCLA) scientists reports this week that a 39-year-old man who has been completely paralyzed for four years was…
A recent study indicates that a respiratory pacemaker intended to assist breathing in people with amyotrophic lateral sclerosis (ALS) may actually reduce survival in those with the neurodegenerative disorder. The study, titled “Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis…
In a recent study entitled “Complex Inflammation mRNA-Related Response in ALS is Region Dependent” characterizes the inflammatory response in patients with Amyotrophic lateral sclerosis (ALS)” published in the journal Neural Plasticity, a research team led by Isidre Ferrer from the L’Hospitalet de Llobregat in Spain detected…
Synapse Biomedical Inc., a company that commercializes the NeuRx Diaphragm Pacing System (DPS), has recently announced it will be presenting data on the company’s Post Approval Study (PAS), a multi-center trial that demonstrated DPS’s safety and survival benefit, during the 26th International Symposium on ALS/MND. Data will be presented by Dr. Robert Miller, Principal Investigator of the…
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Two New Studies Identify Disrupted Trafficking Inside Neurons as the Cause for Known ALS Mutation
Two new studies, one entitled “GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport” and another “The C9orf72 repeat expansion disrupts nucleocytoplasmic transport”, report the discovery of a key mechanism underlying amyotrophic lateral sclerosis’ onset which is associated with C9orf72 mutation (the most common genetic defect…
Last year the Ice Bucket Challenge made headlines across America when the Barrow Neurological Institute raised more than $500,000 through the international fundraising and advocacy initiative. Now, the organization is reporting that the funds accumulated will be used to support a new and potentially groundbreaking amyotrophic lateral sclerosis (ALS) study to determine why…
Diet has a significant influence on a person’s health status because it determines which nutrients are available for the body to function properly. Depending on the balance between diet and energy, body mass index (BMI) is also significantly influential to an individual’s health. Since the effects of diet on developing…
Portage Biotech, Inc. together with privately-held Biohaven Pharmaceutical Holding Company Ltd. has just acquired global intellectual property rights to an extensive 300-product portfolio by ALS Biopharma, LLC. These prodrugs included in the line up, most of which are classified as New Molecular Entities (NMEs), were originally designed and prepared by…
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