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    • #21446
      NJGuy
      Participant

      Hi All

      Hope you are in great spirit!

      I came across this news: a breakthrough discovery at Tel Aviv University :

      https://english.tau.ac.il/news/reversing_als_2021#:~:text=New%20Tool%20for%20Combating%20the,nerve%20cells%20(motor%20neurons).

      This addresses the problem of TDP-43 protein misfolding.

      My question is: there is already a drug Aduhelm which is a new drug for Alzheimer and it addresses the same issue of dissolving amyloid in brain. Can this not be used for treating pALS?

      Best regards

       

       

       

       

    • #21458

      Hi NJGuy,

      > a drug Aduhelm which is a new drug for Alzheimer and it addresses the same issue of dissolving amyloid in brain. Can this not be used for treating pALS?

      As far I understand it, it is not the same issue. Nobody knows the cause of Alzheimer’s disease and there are two main competing hypotheses:
      – It’s a buildup of extracellular amyloid plaques
      – It’s an intracellular buildup of Tau protein.

      In ALS there is a buildup of intracellular TDP-43

      That said it’s an extreme simplification as there are many other proteins involved in both diseases.

      Yet it seems that many scientists and biotechs are working on antibodies or intrabodies (a smaller version of antibodies), so I expect to see good news on the clinical side soon.

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