Newer ALS diagnostic criteria more sensitive than older approaches

A newer set of diagnostic criteria for amyotrophic lateral sclerosis (ALS) was significantly more sensitive at identifying people with the disease than two older diagnostic approaches, a real-world study in Germany found. Among more than 400 people ultimately diagnosed with ALS, these Gold Coast criteria correctly identified 92.5% of…

The challenges of caregiving have been in the news lately. Last year, Dolly Parton appeared in a video following the death of her husband, Carl Dean, to quell rumors about her own poor health after the cancellation of some shows. She said, “Back when my husband, Carl, was very sick,…

Neurosense Therapeutics is revamping its development plan for PrimeC, the company’s experimental oral therapy for amyotrophic lateral sclerosis (ALS). The updated plan includes a new study that will directly compare PrimeC against an approved ALS treatment, as well as a restructured Phase 3 trial and analyses of…

A few months ago, my husband and I decided it was time to replace the mattress set we’d slept on for the past 10 years. Though originally high-quality, its firmness had faded to the point that our bodies left two permanent troughs where we snoozed each night. Who knew a…

BTT Medical Institute is launching an early-stage clinical trial to test the safety of the Abreu BTT 700 Temperature Management System — a device that slowly raises body temperature to induce a controlled fever — with the goal of developing it as a possible treatment for amyotrophic lateral…

The U.S. Food and Drug Administration (FDA) has granted fast-track designation to CK0803, an experimental T-cell therapy from Cellenkos that’s currently in Phase 1 clinical testing for people with amyotrophic lateral sclerosis (ALS). The designation aims to accelerate the clinical development and regulatory review of new treatments that…

When my late husband, Craig, was diagnosed with ALS, we were very naïve and didn’t really know much about the disease. ALS has since been in the media more, so now people have more of an appreciation of what it means to have it. The only thing we knew…

ALN-SOD, an experimental RNA-based therapy being developed for a genetic subtype of amyotrophic lateral sclerosis (ALS) called SOD1-ALS, showed an “encouraging” safety profile and preliminary signs of potential efficacy, according to early results from a Phase 1b/2 study. Biomarker data from participants in the first-in-human Phase 1b/2 GOALS…

My husband, Todd, and I celebrated our 23rd wedding anniversary this week. We’ve spent 16 of those years with ALS since Todd’s diagnosis in 2010. I’ve been thinking recently about how we have found meaning within this difficult life we’ve been living for so long. Todd and Kristin…

For Emmy award-winning host and New York Times bestselling author Tabitha Brown, joy, gratitude, and hope have guided her through life since losing her mother to amyotrophic lateral sclerosis (ALS) in 2007. Speaking this week at the ALS Nexus conference in Orlando, Florida, and online, Brown shared how…