ISIS Pharmaceuticals, in collaboration with Biogen, has started a Phase 1/2 clinical study of ISIS-SOD1Rx (BIIB067), one of the drug candidates to come out of the strategic partnership between the two companies, in adult patients diagnosed with amyotrophic lateral sclerosis (ALS). ISIS-SOD1Rx’s mode of action relies on ISIS antisense technology that targets at…
ALS News Today has published daily coverage of ALS-related advocacy events, clinical trials, and research throughout the year. As 2015 finally winds down, ALS News Today has compiled the top 10 ALS news stories of 2015, ranked according to the number of views each news story received. #10 — “Mechanism Underlying…
MediciNova, Inc. announced its experimental therapy MN-166 (ibudilast) received Fast Track designation from the U.S. Food and Drug Administration (FDA) for the treatment of patients with amyotrophic lateral sclerosis (ALS). The announcement arrived just after MediciNova presented positive interim data from ibudilast‘s ongoing clinical trial to evaluate the drug’s efficacy and…
MediciNova has presented positive interim data from an ongoing clinical trial to evaluate the efficacy and safety of MN-166 (ibudilast) in the treatment of amyotrophic lateral sclerosis (ALS). The study, entitled “Adaptive Design Single Center Phosphodiesterase Type 4 (PDE4) Inhibitor – Ibudilast (MN-166) Phase 1b/2a Clinical Trial [NCT02238626] for Amyotrophic Lateral…
The Augmentative Communication Program (ACP) at Boston Children’s Hospital has received a $1.5 million donation to set up a program focused on improving the quality of life of amyotrophic lateral sclerosis (ALS) adult patients. ALS is a progressive neurodegenerative disease with no treatment to date. The new program will be dedicated to…
Flex Pharma, Inc., a biotechnology company developing novel proprietary treatments for spasms and nocturnal and exercise muscle cramps associated with severe neuromuscular diseases, like amyotrophic lateral sclerosis (ALS) and motor neuron disease (MND), recently presented data demonstrating the role of efficacy of combinations of two molecules, TRPA1 and TRPV1 agonists, in reducing muscle cramp…
MediciNova, Inc., a biopharmaceutical company that acquires and develops novel, small-molecule therapeutics for diseases with unmet medical needs, recently announced that data from the ongoing clinical trial of MN-166 (ibudilast) in patients with amyotrophic lateral sclerosis (ALS) will be presented at the 6th Annual California ALS Pac10 and Research Network Meeting in January 2016. MN-166…
A new multidisciplinary clinic, the Jefferson Weinberg ALS Center, has announced it will open its doors on January 8th 2016. The new clinic will merge with the already settled Frances and Joseph Weinberg Unit for ALS Research leading to a new comprehensive clinical and research integrated center that will offer patients a…
The first transgenic mouse model for the most common type of the familial form of amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) has been developed by Cedars-Sinai scientists. Their research paper, titled “C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD,” was published in…
A recent paper from French researchers questions one of the primary ideas about what causes amyotrophic lateral sclerosis (ALS), and proposes that over-active nervous system cells are not a primary cause of the neurodegenerative disease. The paper, titled “Is hyperexcitability really guilty in amyotrophic lateral sclerosis?” appeared…
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