Scientists at St. Jude Children’s Research Hospital may have unlocked the key to understanding amyotrophic lateral sclerosis (ALS) and other similar diseases of the nervous system. The study, titled “Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization,” appeared in the September…
Stress Granules May Be Key to ALS and Related Diseases
A new study published in the journal Neuron, conducted by Helene Tran, Ph.D. and Fen-Biao Gao, Ph.D., from the University of Massachusetts Medical School, provides insights in the pathogenic consequences of the most common genetic mutation causing ALS (Amyotrophic Lateral Sclerosis). ALS is an incurable and rapidly…
The ALS Association, the nation’s leading non-profit organization dedicated to addressing Lou Gehrig’s disease in both research initiatives and patient support services, recently announced the launch of new partnerships with several hospitals and academic institutions in a renewed effort to expand the accumulation of biofluids from patients with ALS, for the research…
The Northeast ALS Consortium (NEALS) Data and Safety Monitoring Board (DSMB) recently issued Synapse Biomedical Inc. a notice to suspend amyotrophic lateral sclerosis patient enrolment for a randomized control trial of diaphragm pacing. The suspension of new enrolment was not due to safety concerns, but as a response to the slow rate of patient…
Genervon Biopharmaceuticals has recently announced that one if its lead products, GM604, was able to regulate the levels of a protein called TDP-43 and slow disease progression in amyotrophic lateral sclerosis (ALS) patients. ALS results in the progressive loss of structure and function of neurons, ultimately leading to their death. Symptoms depend…
Neuraltus Pharmaceuticals, Inc. recently announced it has partnered with the Clinigen Group plc’s Idis Managed Access (MA) division to launch a program for the former’s product candidate for amyotrophic lateral sclerosis (ALS), NP001. This agreement effectively makes the program available in several European territories, with an estimated growth to more countries as 2016…
Researchers from the University of Milan (UM), Italy, have recently released findings from their scientific literature review, in an effort to uncover the causes of cellular pathologies that are the hallmark of Amyotrophic Lateral Sclerosis (ALS). The findings entitled, “SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis“, published…
In a recent report published in the PLOS One journal entitled “Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and…
The ALS Association, the country’s premier organization committed to find a cure for ALS and improving the lives of those affected by this rare disease, has just announced the viral and recently relaunched ALS Ice Bucket Challenge has played an integral role in pushing the creation of a new drug development…
News
Johns Hopkins, Cedars-Sinai, and Massachusetts General Partner in Largest Project for Answer ALS
Three prominent health institutions have recently come together to form the country’s largest coordinated and comprehensive initiative against amyotrophic lateral sclerosis (ALS). Last week, Johns Hopkins University’s Robert Packard Center for ALS Research, Cedars-Sinai Medical Center’s Regenerative Medicine Institute and the Massachusetts General Hospital Neurological Clinical Research Institute officially launched a joint…
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