Arrowhead Pharmaceuticals will seek permission later this year for the first clinical trial of ARO-SOD1, its RNA-based therapy for amyotrophic lateral sclerosis (ALS), according to a company press release. Further details about Arrowhead’s plans for testing its investigational RNA therapy are expected at a company Research and…
Last weekend, my 13-year-old son, Isaac, and I spent about five hours replacing transition strips between my husband’s bedroom and the hallway, the master bathroom, and his office. When we built our accessible home over a decade ago, we put hard flooring throughout the house in anticipation that my…
An immune protein that is mostly produced in neurons was found to drive damage to mitochondria, which produce energy for cells, and nerve fiber loss, a study has found. Suppressing the protein, called gasdermin-E (GSDME), prevented nerve fiber loss in cells derived from people with amyotrophic lateral sclerosis (ALS),…
Cold temperatures can activate a complex called the proteasome that cells use to clear themselves of unneeded proteins, including the protein clumps associated with amyotrophic lateral sclerosis (ALS), a new study reports. In cell models of the disease, exposure to cold temperatures for a prolonged time significantly lowered the…
Who knew that losing the ability to roll over in bed was an essential indicator of worsening ALS symptoms? I sure didn’t. That is, not until I was diagnosed with ALS and learned that a whole host of simple everyday behaviors were included in the 12-question functional…
A certified care center of excellence for amyotrophic lateral sclerosis (ALS) has opened in Hackensack Meridian Neuroscience Institute at the Jersey Shore University Medical Center. The ALS Center is part of the medical center’s Dr. Robert H. Harris Neuroscience Treatment Center in Neptune, New Jersey. “Our multidisciplinary…
A first patient has been dosed in a Phase 1 clinical trial evaluating QRL-201, an experimental antisense oligonucleotide (ASO) molecule in treating amyotrophic lateral sclerosis (ALS), the therapy’s developer, QurAlis, announced. Dubbed ANQUR (NCT05633459), the study is reported to be the first into a potential therapy…
When my late husband, Jeff, and I were living with his ALS, we were both drawn to spending time outside. While this wasn’t all that different from our life before ALS, somehow, when faced with his disease, sitting in nature brought a new level of peace that…
Transplants using mesenchymal stromal cells or MSCs — a type of stem cell found in bone marrow — delivered into the spinal canal can significantly extend survival in people with amyotrophic lateral sclerosis (ALS) compared with what would be expected based on their clinical characteristics,…
My husband, Todd, and I used to enjoy heading out on adventures, whether it was driving an hour to Chicagoland for an architectural tour of homes designed by Frank Lloyd Wright or flying halfway around the world to Taiwan and visiting a traditional tea house in a small mountain village.
