Researchers at the University of Alberta and the National Institute for Nanotechnology in Canada recently reported new insights into the misfolding process of proteins from a normal structure to a disease state characteristic of degenerative disorders. The study entitled “Protein misfolding occurs by slow diffusion…
Researchers at the University of California at San Francisco (UCSF) recently revealed new insights into the pathogenesis of neurodegenerative diseases. The study, published in The Journal of Neuroscience, is entitled “The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels”. Mutations in…
In a recent study entitled “Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis – A Population-Based Study” researchers investiagated the link between diabetes and amyotrophic lateral sclerosis, confirming that type 2 diabetes, but not type 1, has a protective role against amyotrophic lateral sclerosis evidenced specially in…
Sigma-Aldrich Corporation recently announced it has established an agreement with XCell Science to launch genetically engineered human neural differentiated cells and the corresponding culture media to advance research in the neurological diseases field. Together with the product portfolio of Sigma-Aldrich, these new products offer unique tools relevant for the…
According to a recent study published in the journal JAMA Neurology, type 2 diabetes is associated with a diminished risk of amyotrophic lateral sclerosis (ALS). The study revealed that the risk is directly associated with the age at diagnosis of diabetes and the age at diagnosis of…
A neural prosthetic device surgically implanted in Erik G. Sorto, 34, left quadriplegic by gunshot wound 13 years ago, has enabled the single father of two to now move a robotic arm via only thought input. This major breakthrough is the outcome of a clinical collaboration between The California Institute…
AB Science SA, a pharmaceutical company focused on research, development and marketing of protein kinase inhibitors (PKIs), has announced that it is hosting a web conference including key opinion leaders and experts covering its experimental therapy masitinib and its utility to treat amyotrophic lateral sclerosis (ALS). The web conference call will be held from 5:35…
A new study recently published in the journal Acta Neuropathologica Communications revealed that the absence of the FUS/TLS protein, which has been linked to neurological diseases, causes symptoms distinct from the ones found in amyotrophic lateral sclerosis (ALS) patients. The study is entitled “FUS/TLS…
To better understand amyotrophic lateral sclerosis (ALS), a research team at Johns Hopkins Medicine was able to transform skin cells from ALS and Lou Gehrig’s disease patients into brain cells affected by this severe condition. The researchers deposited the human-made cells derived from the study into the first…
A study published in the latest edition of Nature Immunology presents evidence that a key protein associated with Amyotrophic lateral sclerosis (ALS) also plays an important role in a patient’s immune response to viral infections. The study entitled, “Senataxin suppresses the antiviral transcriptional…
