Medicines used for ovarian and breast cancer, called PARP inhibitors, might be repurposed to treat people with amyotrophic lateral sclerosis (ALS), a study in cells suggests. This suggestion came from researchers’ work with veliparib (ABT-888), an investigational PARP inhibitor, that found it effectively reduced TDP-43 aggregates — a hallmark of…
In the Ken Burns documentary, “Baseball,” during the episode titled “Eighth Inning: A Whole New Ballgame,” comedian Billy Crystal mentions in passing the (I assume fictional) name Al Smenglevitz. Years later, I co-opted the character as a coping mechanism — an alter ego. Only, I simply refer to…
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are caused by different patterns of inflammation in the brain, which may help explain why these two illnesses are so distinct. The German study, “Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the…
Retrotope is providing its investigational fatty acid being developed for Friedreich’s ataxia, RT001, to people with amyotrophic lateral sclerosis (ALS) under an expanded access program, also called “compassionate use.” Individual patients with life-threatening or severely debilitating diseases can petition the U.S. Food and Drug Administration, through their physicians,…
A new process by which pro-death signaling is sent to nerve cells may hold the key for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), which is characterized by the loss of motor nerve cells, according to researchers. The study, “Retrograde degenerative signaling mediated by the p75…
The Wadsworth Brain-Computer Interface (BCI) can help amyotrophic lateral sclerosis (ALS) patients who are severely disabled to communicate while in the home, a study reports, especially those in fairly stable health. Improvements underway to this system, which relies on brain signals rather than muscles necessary for speaking or writing, are…
Cytokinetics has awarded the ALS Association Golden West Chapter with its first communications fellowship, part of a company initiative directed at nonprofit organizations to increase public education and awareness of their programs and care services, as well as to elevate patients’ voices. “As a longstanding partner…
The balance between copper isotopes (variants) – but not copper levels – is disrupted in patients with amyotrophic lateral sclerosis (ALS), according to a recent study. Copper isotope composition potentially may be used as a biomarker of ALS, distinguishing it from other neurodegenerative diseases, such as Alzheimer’s. The study, “…
Combining structural brain imaging with molecular and clinical biomarkers allows for a detailed assessment of a patient’s clinical state, regardless of age and amyotrophic lateral sclerosis progression, a new study suggests. The study, “Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of…
Impaired tightening of the pharynx is associated with inefficient swallowing in patients with amyotrophic lateral sclerosis (ALS), according to a new study. The study, “Reduced pharyngeal constriction is associated with impaired swallowing efficiency in Amyotrophic Lateral Sclerosis (ALS),” appeared in the journal Neurogastroenterology & Motility.
