Neuraltus Pharmaceuticals has enrolled 50 of the 120 patients it hopes to obtain for a confirmatory Phase 2 clinical trial evaluating NP001 as a treatment for amyotrophic lateral sclerosis (ALS). Completion of enrollment is expected in mid-2017, with Neuraltus shooting for results in early 2018. Eighteen clinical sites across North…
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Researchers have developed a molecule called 123C4 that targets the EphA4 receptor, which is known to contribute to the development of amyotrophic lateral sclerosis (ALS), according to a new study. The paper, “Potent and Selective Epha4 Agonists for the Treatment of ALS,” appeared in the journal Cell Chemical Biology. Its…
Patients with chronic conditions like amyotrophic lateral sclerosis (ALS) are as concerned as the general population about health care costs, but see benefits in the Affordable Care Act (ACA) that the healthy may have overlooked, a poll indicates. These findings are reported in a new large-scale poll assessing patient…
Swiss drugmaker GeNeuro has signed an agreement with the National Institute of Neurological Disorders and Stroke (NINDS) — part of the U.S. National Institutes of Health (NIH) — to advance studies of its novel therapeutic antibodies for the treatment of amyotrophic lateral sclerosis (ALS). Under the Cooperative Research and Development Agreement, GeNeuro will…
Natural substances that restore intestinal-bacteria balance may help in the treatment of amyotrophic lateral sclerosis (ALS), according to a study funded by the international Ice Bucket Challenge. Noting that changes in intestinal bacteria contribute to ALS, researchers said using probiotics could restore the balance. The research, “Target Intestinal Microbiota…
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Understanding Molecular Changes in ALS
In this TEDx Talks video, Steven Boeynaems explains that although we have known about amyotrophic lateral sclerosis (ALS) for 140 years, scientists still know very little about the condition that affects around 200,000 people worldwide. Discover seven interesting facts about ALS here. Boeynaems talks about the role of TDP-43 proteins…
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ALS Stories: Todd Walker
This 2014 Roundabout U video is all about Todd Walker from Murray, Kentucky. Todd shares his ALS story, which began when he was suddenly unable to exercise like he usually did. At first, doctors thought Todd was suffering from depression as he had just lost his father but as his…
Being diagnosed with amyotrophic lateral sclerosis (ALS) can be devastating for patients and their families and friends, but there are ways to move forward. We’ve put together a list of coping strategies to help you get through the first few weeks with help from the Mayo Clinic and ALSWindsor.ca. Allow Time and Space…
BrainStorm Cell Therapeutics has validated the cryopreservation process for its NurOwn stem cells to be used in an upcoming Phase 3 clinical trial in amyotrophic lateral sclerosis (ALS). In the validation study researchers compared NurOwn (MSC-NTF cells) derived from fresh mesenchymal stem cells (MSC) to those derived from…
Feeding mouse models of amyotrophic lateral sclerosis (ALS) the bacterial product butyrate improved their gut health, delayed the onset of movement symptoms, and increased the animals’ life span, according to a study. The study reporting the findings, “Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral…