Damaged activity of RNA-binding proteins (RBPs) associated with amyotrophic lateral sclerosis (ALS) can be alleviated by inducing autophagy, a process where cells degrade or recycle components that are damaged or no longer needed, a study says. The study, “FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins…

The patterns of methylation in arginine residues circulating in the cerebrospinal fluid — the liquid that circulates in the brain and spinal cord — could be a strong indicator of disease progression and prognosis among patients with amyotrophic lateral sclerosis (ALS). The study, “Increase of arginine dimethylation correlates…

The Muscular Dystrophy Association (MDA) is financing eight new research projects aimed at developing new treatments and markers of disease progression for amyotrophic lateral sclerosis (ALS). The projects will investigate ALS mechanisms of disease, genetic causes, and pinpoint new therapy targets that can be used to develop better treatments. The…

The first group of teenagers and young adults has been chosen to participate in Mitsubishi Tanabe Pharma America’s (MTPA) ALSO US project, designed to promote awareness of the issues young people face when a parent or other loved one is diagnosed with amyotrophic lateral sclerosis (ALS). Participants…

Transplanting certain human bone marrow cells into mice with amyotrophic lateral sclerosis (ALS) improved their motor function and preserved motor neurons by repairing the barrier protecting the spinal cord. The study with that finding, “Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease…

The Australian non-profit organization FightMND has awarded Lauren Sciences a AU$1 million ($710,000 US) grant to further the biotechnology company’s development of a new treatment for amyotrophic lateral sclerosis (ALS). Specifically, the New York-based biotechnology company will use the funds to advance LAUR-301, a medicine that aims…

For more than four decades, comedian Jerry Lewis hosted the MDA Labor Day Telethon on behalf of the Muscular Dystrophy Association. That annual event helped the MDA become the nation’s largest non-government source of funding for neuromuscular disease research, with more than $1.4 billion disbursed since its establishment 68…

Differences in blood parameters, such as total protein levels, are associated with different stages of amyotrophic lateral sclerosis (ALS), meaning they could become valuable biomarkers to track disease progression in clinical practice, a study suggests. The study, “Clinical disease stage related changes of serological factors in amyotrophic lateral…

Mitsubishi Tanabe Pharma America (MTPA), in collaboration with the Massachusetts General Hospital (MGH), is conducting a study to identify biomarkers related to amyotrophic lateral sclerosis (ALS), which may be helpful to measure patient response to Radicava (edaravone). The study will be sponsored by MTPA, Radicava’s seller in…

Amyotrophic lateral sclerosis (ALS) prevalence in a large group of patients with Medicare coverage was found to be higher than that previously reported in the U.S., according to a study. Findings also revealed that having ALS was associated with shorter survival than other motor neuron diseases (MND). The study,…