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Do Over-active Neurons Actually Cause Amyotrophic Lateral Sclerosis?
A recent paper from French researchers questions one of the primary ideas about what causes amyotrophic lateral sclerosis (ALS), and proposes that over-active nervous system cells are not a primary cause of the neurodegenerative disease. The paper, titled “Is hyperexcitability really guilty in amyotrophic lateral sclerosis?” appeared…
Abnormal Enzyme SOD1 Increases Amyloid Precursor Protein Activity in ALS
Israeli researchers may have found that a protein related to Alzheimer’s disease can also run amuck in amylotrophic lateral sclerosis (ALS). The report, titled “Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS” appeared November 24th in PLoS One. In…
New Amyotrophic Lateral Sclerosis Biomarker Identified in Study
Researchers have discovered a potential new biomarker for amyotropic lateral sclerosis (ALS) — microRNA-206 — from studies using an experimental mouse model and the blood serum of 12 people with ALS. The report describing their research, titled “MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis,” appeared in the…
ALS, in Some Forms, May Be Caused by Activated Retrovirus
Some forms of amyotrophic lateral sclerosis (ALS) could actually be caused by an infectious virus, with scientists reporting that human endogenous retrovirus-K (HERV-K), normally dormant, has been found in an active form in the postmortem brain cells of certain individuals with ALS. Experiments using the active HERV-K in cells grown in…
Ubiquilin-2 May Be Future Target for ALS Treatment
A recent study from researchers in Canada and Japan describes a new possible target for the treatment of amyotrophic lateral sclerosis (ALS). The paper, titled “Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells,” appeared on Oct. 31 in the journal Molecular Brain.
Amyotrophic Lateral Sclerosis Linked to Deficient Translation of RNA into Proteins
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS) all share a disease hallmark, the aggregation of “misfolded” proteins. Understanding the molecular processes underlying protein aggregation and how it leads to disease is an important step toward developing new therapies. Now, researchers at the University of Cambridge, in…
Amyotrophic Lateral Sclerosis Biomarkers May Exist in Plasma
Japanese researchers have found possible biomarkers that could aid in the early detection of amyotrophic lateral sclerosis (ALS). The report, titled “Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis” appeared on Oct. 24 in the journal Molecular Brain. In ALS…
Stress Granules May Be Key to ALS and Related Diseases
Scientists at St. Jude Children’s Research Hospital may have unlocked the key to understanding amyotrophic lateral sclerosis (ALS) and other similar diseases of the nervous system. The study, titled “Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization,” appeared in the September…
Device That Aids Breathing in ALS Patients May Decrease Survival
A recent study indicates that a respiratory pacemaker intended to assist breathing in people with amyotrophic lateral sclerosis (ALS) may actually reduce survival in those with the neurodegenerative disorder. The study, titled “Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis…