SPG302, an experimental oral therapy for amyotrophic lateral sclerosis (ALS), was well tolerated in an early clinical trial, and initial findings suggest it may help slow disease progression. The new data come from a Phase 1/2a study (NCT05882695) conducted in Australia. The first parts of the study tested…
A new blood test that analyzes tiny fragments of DNA released by dying cells may help diagnose amyotrophic lateral sclerosis (ALS) and predict how quickly the disease will progress, a study suggested. “Our model test could not only distinguish ALS patients from healthy individuals but also from those with other…
Amyotrophic lateral sclerosis (ALS) is more common in some parts of the U.S. than others, and it has a very strong geographic association with multiple sclerosis (MS), a new study suggests. The finding implies that some type of environmental factors may be increasing the risk of both…
People with amyotrophic lateral sclerosis (ALS) who also have diabetes tend to lose the ability to walk faster than non-diabetic patients, according to a study from Japan. The findings underscore the importance of supportive mobility care for diabetic ALS patients, scientists said in the study, “Factors…
EKZ-102, Eikonizo Therapeutics‘s experimental oral therapy for amyotrophic lateral sclerosis (ALS), is on track to enter early clinical testing in 2026, according to an announcement from the company. EKZ-102 is designed to block the activity of a protein called HDAC6. A team led by scientists at Eikonizo…
A pivotal Phase 3 clinical trial testing the oral therapy pridopidine in people with amyotrophic lateral sclerosis (ALS) is expected to start in January, following promising results seen in the HEALEY ALS platform trial. Pending regulatory clearance, enrollment will begin at ALS treatment centers in the U.S., Canada,…
In a new study by a team of U.S. scientists, a group of inflammatory immune cells was found to mistakenly target the C9ORF72 protein in nerve cells in people with amyotrophic lateral sclerosis (ALS) — demonstrating that ALS may be an autoimmune disease. The findings, by researchers at the…
Analyzing single strands of hair has shown researchers that the dynamics of certain metal molecules, such as copper and zinc, in the body are altered in amyotrophic lateral sclerosis (ALS). The scientists hope to build on this discovery to develop a new, noninvasive diagnostic test for the neurodegenerative condition.
Through analyses of blood samples from hundreds of patients, researchers have developed a highly accurate test for diagnosing amyotrophic lateral sclerosis (ALS). The test is based on a unique protein signature in the blood that may be able to detect ALS-related changes up to 10 years before symptoms of…
New research is bringing mind-to-speech technology a step closer to reality for people with paralysis, including those with amyotrophic lateral sclerosis (ALS) who lose the ability to speak. A proof-of-principle study shows that a brain-computer interface (BCI) can translate a person’s silent thoughts into spoken words and could provide…
