Wave Life’s WVE-004 Shows Proof of Concept in Cell, Mouse Models
WVE-004, Wave Life Sciences‘ experimental therapy for people with amyotrophic lateral sclerosis (ALS)Â associated with mutations in the C9ORF72…
Articles by Marisa Wexler, MS
Treg Therapy ALS001 Found to Ease Oxidative Stress in Early Trial
Treatment with Coya Therapeutics‘ ALS001, a regulatory T-cell (Treg) therapy being developed for amyotrophic lateral sclerosis (ALS), was found…
#AAN2022 – Biological Clustering May Help ID Fast-progressing ALS
“Clustering” people with amyotrophic lateral sclerosis (ALS) based on biological data could be useful for identifying those most likely…
WVE-004 Reduces Toxic Proteins, Early FOCUS-C9 Data Suggests
The experimental therapy WVE-004 appears to be engaging its intended target and reducing the amount of toxic proteins in people…
RNA-targeting CRISPR System Shows Promise in Preclinical Models
A CRISPR-based gene editing system could be used to reduce the activity of genes associated with amyotrophic lateral sclerosis…
Brain Implant Allows Paralyzed ALS Patient to ‘Speak’ With Family Again
A novel system that involves electrodes implanted in the brain allowed a 34-year-old man with amyotrophic lateral sclerosis (ALS)…
Scientists Shed Light on ‘Critical’ Impact of TDP-43 Protein in ALS
Two independent teams of scientists have unraveled the molecular mechanism by which abnormal localization of the TDP-43 protein, which is…
#MDA2022 – NurOwn May Benefit Patients With Specific Gene Variant
Treatment with the cell therapy NurOwn may slow the progression of amyotrophic lateral sclerosis (ALS) for those with…
#MDA2022 – CNM-Au8 May Slow Progression, Reduce Risk of Death
Treatment with Clene Nanomedicine’s experimental medicine CNM-Au8 may decrease the risk of disease progression or death in people with…
BMAA, Formaldehyde Among Toxins in Environment Linked to ALS Risk
Exposure to certain toxic compounds — including beta-N-methylamino-L-alanine (BMAA), formaldehyde, and heavy metals like manganese, mercury, and zinc — increases…