ALS-linked Mutations Promote Accumulation of Brain Waste, Fruit Fly Study Shows
Loss of a protein known as ubiquilin causes defects in degradation centers called lysosomes, promoting the buildup of brain waste in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, a fruit fly study has found. The study, “Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification,” was published in…