Clene is planning to submit an application to the U.S. Food and Drug Administration (FDA) in early 2026 requesting accelerated approval of its oral therapy CNM-Au8 for treating amyotrophic lateral sclerosis (ALS). The company’s announcement follows new, positive data — from FDA-requested analyses — showing that CNM-Au8…
A Phase 2 clinical trial to investigate Tiziana Life Sciences’ intranasal foralumab for the treatment of amyotrophic lateral sclerosis (ALS) has been accepted into the Healey ALS MyMatch program at Massachusetts General Hospital. The program, located at the Sean M. Healey & AMG Center for ALS, is a…
The U.S. Food and Drug Administration (FDA) has authorized Neurosense Therapeutics to begin a pivotal Phase 3 trial of its experimental oral therapy PrimeC for the treatment of amyotrophic lateral sclerosis (ALS). The authorization follows the FDA’s positive feedback on the design of the PARAGON trial and…
The ALS Association is awarding $20,000 grants to 107 eligible clinics across the U.S. to help strengthen multidisciplinary care for people living with amyotrophic lateral sclerosis (ALS) and their families. The funding — totaling $2.14 million — comes from the Hugh and Herbert Hoffman ALS Impact Fund,…
The ALS Network, in collaboration with ALS United, has announced the winners of the 2025 Research Innovation Grants, which support projects aimed at enhancing understanding and care for amyotrophic lateral sclerosis (ALS). This year’s group of 13 awarded research…
A bipartisan team of congressional representatives is pushing for new legislation that aims to understand why veterans are at increased risk of amyotrophic lateral sclerosis (ALS) and develop strategies to reduce this risk. The bill, dubbed the “Veterans with ALS Reporting Act,” was created in partnership with the…
Aperture Therapeutics has selected APRTX-001 as its lead candidate to treat amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The therapy is designed to reduce the levels of CD33, a receptor protein on the surface of microglia — the resident immune cells of the central nervous system (CNS,…
In an upcoming episode of NBC’s TV show “Brilliant Minds,” actor Eric Dane will guest star as a character with amyotrophic lateral sclerosis (ALS), which he is also battling. ALS causes muscle weakness, which leads to other symptoms, such as trouble speaking, swallowing, and breathing. Though the…
M102, an experimental oral therapy designed to simultaneously activate two molecular pathways that protect against nerve cell damage, showed promise in preclinical models of amyotrophic lateral sclerosis (ALS), according to a study. The compound, discovered and developed by researchers at the University of Sheffield’s Institute for Translational Neuroscience (SITraN)…
Inflammasome Therapeutics is teaming up with the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital to conduct a clinical trial evaluating its oral therapy candidate kamuvudine-9, or K9 for short, in people with amyotrophic lateral sclerosis (ALS). The collaboration is part of the Healey…
