Delivering gentle electrical stimulation to the spinal cord can reduce the buildup of toxic TDP-43 protein clumps in a mouse model of amyotrophic lateral sclerosis (ALS), according to a new study. The specific type of stimulation used in the study is known as multisite direct current stimulation (DCS). The…
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A novel treatment for amyotrophic lateral sclerosis (ALS) caused by mutations in a specific gene called CHCHD10 showed promise for slowing disease progression in a clinical trial that tested the therapy in a single individual, as reported in a new study. “I didn’t think I would see this kind of…
Measuring blood levels of toxic TDP-43 protein in astrocyte-derived extracellular vesicles — packets of cellular material released from star-shaped brain support cells called astrocytes — may help diagnose amyotrophic lateral sclerosis (ALS), according to a new study from U.S. researchers. Tests showed that differences in TDP-43 levels inside these…
People with a history of atherosclerotic cardiovascular disease (ASCVD) may have a higher risk of developing amyotrophic lateral sclerosis (ALS), while those with better cardiovascular health may have a lower risk, a large study suggests. Among more than 500,000 people from the U.K. who were followed for nearly 14…
Common viral infections such as influenza and COVID-19 may accelerate the onset and progression of amyotrophic lateral sclerosis (ALS), a new mouse study suggests. “In our pre-clinical models, just one viral infection was enough to significantly accelerate ALS progression, even after the infection itself had resolved,” Art Marzok, PhD,…
The amyotrophic lateral sclerosis (ALS) community is mourning Brooke Eby, an ALS advocate who documented her life with the disease on social media and helped build an online community for people living with ALS. Eby died Thursday, Oct. 1, at age 37. Eby was diagnosed with ALS in…
For many people living with rare neuromuscular diseases, the most meaningful part of a recent Chicago gathering was not just the medical updates — it was finding a community that understood their daily struggles. The realization that they were not alone set the tone for MDA Engage: Chicago, a…
Medicinova has completed the last patient visit in the placebo-controlled portion of the COMBAT-ALS clinical trial, which is evaluating its investigational oral therapy MN-166 (ibudilast) in people with amyotrophic lateral sclerosis (ALS). The Phase 2b/3 trial (NCT04057898) is testing MN-166’s safety and efficacy at slowing disease…
Advocates are cheering as legislation that would renew the Accelerating Access to Critical Therapies (ACT) for amyotrophic lateral sclerosis (ALS) has made its way to President Donald Trump’s desk as the law reaches its Oct. 1 expiration date. ACT for ALS, signed into law in 2021 by President…
Early rehabilitation, a care team that works together, and adequate bracing equipment can help people with neuromuscular diseases stay active and safe, two rehab specialists said. “Every patient has a different journey,” said Sol Abreu-Sosa, MD, a physiatrist at Rush University Medical Center in Chicago. The exercise plan, equipment, or…
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