Up to six people with advanced amyotrophic lateral sclerosis (ALS) will be treated with Trethera’s experimental therapy TRE-515 under a collaboration with Massachusetts General Hospital (MGH). The patients will receive the oral treatment through a U.S. Food and Drug Administration (FDA) expanded access program (EAP), which allows people…
News
A pivotal Phase 3 clinical trial testing pridopidine, an experimental oral therapy being developed by Prilenia Therapeutics and Ferrer, in people with early, rapidly progressive amyotrophic lateral sclerosis (ALS) has enrolled its first participant. PREVAiLS (NCT07322003), which was cleared late last year by the…
Brooke Eby, who was diagnosed with amyotrophic lateral sclerosis (ALS) in 2022 at age 33, has been named the ALS Network’s 2026 Dean and Kathleen Rasmussen Advocate of the Year for turning her personal experience as an ALS patient into a platform for advocacy, community building, and awareness. The…
Tanabe Pharma Canada has announced the publication of a new book featuring personal letters from people living with amyotrophic lateral sclerosis (ALS) and their families, with contributions from advocates, healthcare professionals, and researchers. The book, “Letters to ALS: Our Journeys to Hope,” is available free of charge to…
Insitro and Bristol Myers Squibb have expanded their ongoing collaboration to develop new treatments for amyotrophic lateral sclerosis (ALS), adding two newly identified disease targets to their ongoing research effort. The two drug companies have been working together since 2020 to uncover biological changes driving ALS…
The first patient has been dosed in a small clinical trial in Australia that’s testing CTx1000, Celosia Therapeutics’ experimental gene therapy, in people with amyotrophic lateral sclerosis (ALS). The one-time treatment is designed to reduce toxic buildups of the TDP-43 protein, which are believed to contribute to nerve cell…
ACI-19626, an experimental imaging agent developed by AC Immune, may safely detect abnormal clumps of the protein TDP-43 in the brain, a hallmark of amyotrophic lateral sclerosis (ALS) and other neurological conditions. That’s according to early data from a Phase 1 clinical trial (NCT06891716) evaluating the safety and…
Early treatment with AL-S Pharma‘s infusion therapy AP-101 significantly extended survival and delayed the need for respiratory support in people with amyotrophic lateral sclerosis (ALS), compared with a six-month delay in starting therapy, new trial data show. The therapy candidate is being developed to target and clear…
The ALS Network and ALS United are inviting U.S. researchers to submit proposals for a new round of funding aimed at accelerating progress toward new treatments for amyotrophic lateral sclerosis (ALS). The funding is part of the expanding ALS Research Innovation Initiative. It’s intended to support “bold” and …
Several commonly used medications may be repurposed to extend survival in people with amyotrophic lateral sclerosis (ALS), according to an analysis of the electronic medical records of more than 11,000 U.S. veterans. Researchers found that certain classes of medications were associated with improved survival in ALS, including statins, which…
Recent Posts
- ALS partnership to give 6 patients expanded access to TRE-515
- Frustration mounts when ALS assistive technology isn’t so helpful
- Trial of experimental ALS therapy pridopidine enrolls first participant
- Advocate for ALS patients, including herself, recognized for work
- New book shares personal stories and insights from people living with ALS