News

Researchers, physicians, industry partners, caregivers, and people with amyotrophic lateral sclerosis (ALS) are gearing up to gather for the third annual ALS Nexus conference, an effort from the ALS Association to bring the ALS community together around a shared goal of changing the future of ALS. The…

People with amyotrophic lateral sclerosis (ALS) who have a history of strenuous exercise tend to develop the disease earlier than patients who were less physically active, according to a study. However, data showed that heavy exercise does not increase the risk of death for ALS patients, and exercise itself…

Analyses of vocal recordings using artificial intelligence (AI) may aid in the diagnosis of amyotrophic lateral sclerosis (ALS), particularly among those with a form of the disease called bulbar-onset ALS that initially affects the mouth and throat, a new study suggests. Bulbar-onset ALS generally has a poorer prognosis than…

New analyses of data from two Phase 2 clinical trials and observational studies suggest that changes in blood levels of neurofilament light chain (NfL), a biomarker of nerve damage, may help predict which people with amyotrophic lateral sclerosis (ALS) are more likely to experience clinical benefits with Clene’s…

Neurosense Therapeutics plans to seek Health Canada approval by the end of the year for PrimeC, its experimental oral therapy for amyotrophic lateral sclerosis (ALS). The planned new drug submission (NDS) filing follows completion of a pre-NDS process and finalization of the related meeting minutes. The process is…

People whose jobs expose them to pesticides may be more likely to develop amyotrophic lateral sclerosis (ALS) than workers who aren’t exposed, according to a systematic review and meta-analysis. Researchers found that occupational pesticide exposure was associated with a higher risk of developing ALS. Among different pesticide classes, exposure…

People who sustain a traumatic brain injury (TBI) are more likely to die within two years from amyotrophic lateral sclerosis (ALS), according to a new analysis. But the association may reflect an early manifestation of the disease, rather than a cause. Researchers said a phenomenon called reserve causation may…

Adding a blood test that measures nerve damage or a test of brain activity to standard diagnostic criteria may help doctors diagnose amyotrophic lateral sclerosis (ALS) more accurately, a study suggests. Researchers found that incorporating either blood levels of neurofilament light chain (NfL), a biomarker of nerve cell damage, or…

Treatment with a novel one-time gene therapy improved motor function and extended survival in a mouse model of amyotrophic lateral sclerosis (ALS) driven by mutations in the SOD1 gene, according to researchers from the University of Massachusetts Chan Medical School. The results, the team noted,…

A panel of 19 blood proteins may help estimate when symptoms of amyotrophic lateral sclerosis (ALS) will emerge in people who carry disease-associated genetic variants, a new study suggests. When the model was tested using data from carriers whose symptom-onset dates were known, its estimates differed from the actual timing…