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Study Validates Use of Social Cognition Measure in ALS Patients

Although cognitive impairment is common in patients with ALS, the reliability of the “Reading the Mind in the Eyes Test” (RMET), a measure of social cognitive function, had yet to been established. Here, researchers confirm this is a reliable and efficient measure of social cognition in amyotrophic lateral sclerosis (ALS) patients,…

Glial Cells in Brain Work as Toxic Agents in ALS, Study Reports

Astroglial cells in the brain were seen to contribute to the death of neurons by promoting inflammation in an in vitro laboratory model of sporadic amyotrophic lateral sclerosis (ALS). Astrocytes are brain cells that are usually known for their protective role toward neurons in conditions such as stroke and spinal cord injury. But…

Cytokinetics Enrolls 700 ALS Patients in Phase 3 Study of Tirasemtiv

Cytokinetics recently announced that patient enrollment for its VITALITY-ALS clinical trial is now complete. The study, designed to assess the effects of tirasemtiv, a novel skeletal muscle activator, on respiratory function in ALS patients has enrolled over 700 people at 81 centers in 11 countries. VITALITY-ALS (NCT02496767) is an international, randomized, double-blind and placebo-controlled trial in…