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New Study Uncovers Mechanism of CuATSM, ALS Therapy Now in Trials

CuATSM, a potential amyotrophic lateral sclerosis (ALS) therapy that’s now in clinical trials, may work by altering how certain cells in the brain generate energy, a new study suggests. Researchers say these findings may help to identify patients most likely to respond to the experimental treatment. “Screening patient derived…

Air Pollution Exposure Tied to Greater ALS Risk in Women in Study

Higher long-term exposure to certain forms of air pollution — specifically coarse particulate matter, such as that from traffic pollutants — significantly increases the risk of amyotrophic lateral sclerosis (ALS) in postmenopausal women, a study showed. “Although the effects noted within the current study are limited by sample size…

Machine Learning May Help Predict ALS Progression

Deep machine-learning models using neural networks — computer algorithms inspired in the biological networks of the human brain —may help to predict the course of amyotrophic lateral sclerosis (ALS), a new study reports. The models also consistently showed that a longer delay between disease onset and diagnosis is a…

Via Orphan Drug Grant Program, FDA Funds New ALS Research

The U.S. Food and Drug Administration (FDA) is funding several novel research projects related to amyotrophic lateral sclerosis (ALS) and other rare neurological disorders through its orphan drug grants program. In total, the regulatory agency has awarded 19 new grants and two contracts, providing more than $38 million…

Phase 2 Trial Will Test Cortisol Modulator Dazucorilant in ALS

Dazucorilant, Corcept Therapeutics‘ investigational cortisol modulator for people with amyotrophic lateral sclerosis (ALS), is being evaluated in a Phase 2 clinical trial. The DAZALS Phase 2 study (NCT05407324) aims to determine dazucorilant’s safety and efficacy against a placebo in about 198 adults with ALS. It will be…