FDA Names Ibudilast an Orphan Drug as Possible ALS Treatment

The U.S. Food and Drug Administration (FDA) has designated  MediciNova’s Ibudilast (MN-166) an orphan drug as a potential treatment for amyotrophic lateral sclerosis (ALS). Ibudilast is a first-in-class, orally bioavailable small molecule phosphodiesterase (PDE)-4 and -10 inhibitor and a macrophage migration inhibitory factor (MIF) inhibitor that suppresses pro-inflammatory cytokines and promotes neurotrophic factors.

In this Houston Methodist video, we get to meet Kevin Kinchen. Kevin was diagnosed with amyotrophic lateral sclerosis (ALS) six years ago, but he hasn’t let that stop him from getting on with his life.  Nanci is a much-loved Hollywood publicist who was diagnosed with amyotrophic lateral sclerosis (ALS)…

Patients with amyotrophic lateral sclerosis (ALS) experience a gradual loss of the ability to walk, swallow and even breathe, and there’s no cure. It’s incredibly important that patients seek specialized treatment to address the different aspects of the disease. Find out seven ways to diagnose ALS. In this…

An analysis of previously published data suggests that neurofilaments in the blood and spinal fluid of people with amyotrophic lateral sclerosis (ALS) may be used to assess disease progression and neurodegeneration in general. Levels of the factor also were higher in ALS patients than in patients with diseases mimicking ALS,…

Augie’s Quest announced the 11th annual ‘Tradition of Hope’ gala event will be held Oct. 15 at the Beverly Hilton Hotel to raise funds for amyotrophic lateral sclerosis (ALS) research. Augie’s Quest is a cure-driven nonprofit effort dedicated to finding treatments and a cure for ALS. The effort…

Turmeric & Ginger are Antioxidants Fall is the perfect season to drink spice teas. This ginger and turmeric tea recipe is chock-full of antioxidants. Merriam Webster defines antioxidants as a substance (as beta-carotene or vitamin C) that inhibits oxidation or reactions promoted by oxygen, peroxides, or free radicals…

AB Science has been invited to present new preclinical studies on masitinib in the treatment of amyotrophic lateral sclerosis (ALS) at four international meetings this year. These were the main findings from the series of preclinical studies: Proof of concept data from the preclinical trials of masitinib showed that the investigational drug “targets…

Find out more about the story of Nanci Ryder in this ALS Association video. Nanci is a much-loved Hollywood publicist who was diagnosed with amyotrophic lateral sclerosis (ALS) in 2014. Read about the four ALS heroes the ALS Association chose to honor for outstanding contributions.  The ALS Association’s…

It’s that time of year when everyone starts to get sick and pass around their cold and flu germs. Having a chronic illness means that your immune system is already compromised, which makes picking up other people’s winter illnesses harder to avoid. However, you don’t have to lock yourself away…

Amyotrophic lateral sclerosis (ALS) would benefit from a new classification system, according to a group of researchers who highlighted the shortcomings of current systems for diagnosing the disease and allocating patients to subtypes of the condition. The opinion article, “Amyotrophic lateral sclerosis: moving towards a new classification…