Amyotrophic lateral sclerosis, also know as ALS or Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. There are two different types of ALS: sporadic and familial. To help you understand more about this disease, we’ve put together a list with…
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In a recent study entitled “Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis – A Population-Based Study” researchers investiagated the link between diabetes and amyotrophic lateral sclerosis, confirming that type 2 diabetes, but not type 1, has a protective role against amyotrophic lateral sclerosis evidenced specially in…
The exact cause of amyotrophic lateral sclerosis (ALS) is largely unknown, but a number of factors including genetics, environmental exposures, and lifestyle habits have been linked to an increased risk of ALS.
A partnership between LifeArc and the UK Dementia Research Institute (UK DRI) is awarding £14.5 million (about $18.2 million) to seven research projects aimed at developing new tests, treatments, and devices for neurodegenerative diseases. “Our partnership with UK DRI allows us to identify and back the most promising translational…
NeuroSense Therapeutics has joined researchers at Massachusetts General Hospital to study the impact of its investigational therapy PrimeC on key amyotrophic lateral sclerosis (ALS) processes. The collaboration will the headed by Ghazaleh Sadri-Vakili, director of the Neuroepigenetics laboratory at the MassGeneral Institute for Neurodegenerative Disease. Using a new…
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Explaining the Early Symptoms of ALS
In this University of California TV video, Dr. Geoffrey Sheean from the School of Medicine, UC San Diego, talks about the early stages of amyotrophic lateral sclerosis (ALS). MORE: Explaining the progression of ALS Dr. Sheean explains that often the first signs of the…
A new study recently published in the journal Acta Neuropathologica Communications revealed that the absence of the FUS/TLS protein, which has been linked to neurological diseases, causes symptoms distinct from the ones found in amyotrophic lateral sclerosis (ALS) patients. The study is entitled “FUS/TLS…
The accumulation of TDP-43, a widely expressed nuclear protein that binds both DNA and RNA, causes RNA instability in nerve cells derived from patients with amyotrophic lateral sclerosis (ALS). That leads to disruption of energy and protein production, and eventually causes cells’ death. Those findings were described in the…
Researchers at the Second University of Naples and the University of Parma in Italy recently characterized the microstructural brain alterations in patients with amyotrophic lateral sclerosis (ALS) during disease progression. The findings were published in the journal PLoS ONE and the study is entitled…
Researchers reviewed both current and emerging technical approaches that show the most promise in the detection of upper motor neuron (UMN) degeneration of ALS patients. By assessing and comparing the utility of cutting-edge imaging and electrophysiological approaches, researchers hope to identify biomarkers for UMN dysfunction that can serve as early diagnostics for…