Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease. It is characterized by the destruction of motor neurons or nerve cells that control muscle movement, leading to disability. Incidence of ALS The average incidence rate of ALS worldwide is about one in…
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Having possible symptoms of amyotrophic lateral sclerosis (ALS) increases the chances of getting an ALS diagnosis by nearly five times, but getting diagnosed is more likely for people in urban areas, who have greater access to specialized care, a U.S. study shows. People in rural areas are diagnosed at…
Amyotrophic lateral sclerosis (ALS) is a disease that progressively shuts down your muscles by attacking certain cells in the brain and spinal cord needed to keep our muscles moving. Eventually, patients will lose their mobility, have trouble moving, walking, swallowing and even breathing. In this video, shared by …
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Discussing Overactive Neurons and ALS
A recent paper from French researchers questions one of the primary ideas about what causes amyotrophic lateral sclerosis (ALS), and proposes that overactive nervous system cells are not a primary cause of the neurodegenerative disease. The paper, titled “Is hyperexcitability really guilty in amyotrophic lateral sclerosis?” appeared in…
Chemists from Cornell University, using a technique that illuminates very subtle changes in individual proteins, may have found new evidence about the underlying causes of Amyotrophic Lateral Sclerosis (ALS). Professor of chemical biology and chemistry Brian Crane led a study and co-authored a follow-up based on a spectroscopic method that is…
Amyotrophic lateral sclerosis (ALS) is a disease that progressively shuts down your muscles by attacking certain cells in the brain and spinal cord needed to keep our muscles moving. Eventually, patients will lose their mobility, have trouble moving, walking, swallowing and even breathing. In this video, shared by …
Researchers detected changes in the production of several immune signaling proteins, called cytokines, in the cerebrospinal fluid (CSF) — the liquid that surrounds the brain and spinal cord — of people with amyotrophic lateral sclerosis (ALS) at diagnosis. These changes also correlated with certain clinical characteristics, and how quickly the…
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Two New Studies Identify Disrupted Trafficking Inside Neurons as the Cause for Known ALS Mutation
Two new studies, one entitled “GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport” and another “The C9orf72 repeat expansion disrupts nucleocytoplasmic transport”, report the discovery of a key mechanism underlying amyotrophic lateral sclerosis’ onset which is associated with C9orf72 mutation (the most common genetic defect…
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Explaining Early Symptoms of ALS
https://vimeo.com/168979927 In this short video from the ALS Association Texas Chapter, the early symptoms of amyotrophic lateral sclerosis (ALS) are discussed using simple computer-generated animation. Discover seven facts about ALS you might find interesting. ALS is difficult to diagnose in the early stages as the symptoms presented can often…
To better understand amyotrophic lateral sclerosis (ALS), a research team at Johns Hopkins Medicine was able to transform skin cells from ALS and Lou Gehrig’s disease patients into brain cells affected by this severe condition. The researchers deposited the human-made cells derived from the study into the first…