Researchers at The Scripps Research Institute in California found that a particular enzyme has a harmful ability to create inflammatory lipid molecules in the brain, and is implicated in a rare neuroimmunological disorder, called PHARC – characterized by polyneuropathy, hearing loss, ataxia, retinitis pigmentosa and cataract. The disorder usually begins onset during adolescence and gradually gets worse with…
A new study entitled “Vitamin D deficiency and its supplementation in patients with amyotrophic lateral sclerosis” suggests that further studies are needed to understand if supplementing Vitamin D in patients with amyotrophic lateral sclerosis is capable of delaying disease progression. The study is published in the…
NEALS will be holding its first annual Virtual ALS Clinical Research Learning Institute (CRLI) this month, January 2015, that will discuss amyotrophic lateral sclerosis (ALS). The ALS CRLI will be sponsored by the ALS Association’s TREAT ALS initiative. The ALS Clinical Research Learning Institute is an intensive program whose goal is to educate…
A new study on amyotrophic lateral sclerosis (ALS), entitled, “ATXN2 polyQ intermediate repeats are a modifier of ALS survival” published in Neurology by Dr. A. Chiò from the ALS Center, Department of Neuroscience, University of Torino in Italy, evaluated the rate of…
BrainStorm Cell Therapeutics, Inc., a biotechnology company focused on developing innovative, autologous stem cell therapies for highly debilitating neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), recently announced the latest Phase 2a clinical trial results of NurOwn™, a technology that differentiates bone marrow-derived mesenchymal…
Recent evidence shows that in amyotrophic lateral sclerosis (ALS), there occurs a notable deposition of abnormal ubiquitinated inclusions immunoreactive to TDP-43. In order to provide an early diagnosis and to conduct clinical trials for early treatment for ALS, it is crucial to fully understand muscle pathology in this condition. The study, entitled,…
A recent review, entitled, “Patient-Perceived Outcomes and Quality of Life in ALS”, which was published in the journal Neurotherapeutics last December 11, 2014, examined current evidence concerning the Quality of Life assessment measures for patients with amyotrophic lateral sclerosis (ALS). The…
In trying to determine the basis for volumetric changes seen in patients with amyotrophic lateral sclerosis (ALS), Drs. Venkateswaran Rajagopalan and Erik Pioro of the Cleveland Clinic have used voxel based morphometry to measure motor and extramotor grey matter volumes. The two recently delved into a study,…
The accumulation of specific metals may trigger neuronal degeneration associated with Amyotrophic lateral sclerosis (ALS), according to a study conducted on residents of the Kii Peninsula in Japan. The study, titled, “Neutron Activation Analysis of Scalp Hair from ALS Patients and Residents in the Kii Peninsula, Japan” was…
A new clinical review entitled “Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?”, conducted by Christopher Donnelly from the Department of Neurology of the Johns Hopkins University and colleagues, explores the current status of Amyotrophic lateral sclerosis (ALS) evidence. The study was published…
