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August 6, 2019 News by Joana Carvalho, PhD

Animal Study Links Inactivation of the Autophagy Gene ATG7 to the Onset of ALS, FTD

Inactivation of ATG7, one of the genes that controls autophagy — a process in which cells degrade or recycle components that are damaged or no longer needed — is linked to the onset of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a study says. Results from…

June 19, 2019 News by Alejandra Viviescas, PhD

Increased Glucose Levels Might Protect Nerve Cells in ALS, Study in Fruit Flies Shows

High glucose levels might compensate for the toxic effects of an accumulation of TDP-43 — a widely expressed nuclear protein that binds both DNA and RNA — and protect neurons in amyotrophic lateral sclerosis (ALS), a study in a fly model of the disease suggests. The study,…

February 27, 2019 News by Patricia Inácio, PhD

ALS-linked Mutations Promote Accumulation of Brain Waste, Fruit Fly Study Shows

Loss of a protein known as ubiquilin causes defects in degradation centers called lysosomes, promoting the buildup of brain waste in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, a fruit fly study has found. The study, “Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification,” was published in…

Recent Posts

  • Crunch Fitness hosts exercise event for Augie’s Quest to Cure ALS
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  • Finding humor lifts our spirits in life with ALS
  • FDA clears expanded access program for SPG302 in ALS patients
  • A mayday call to raise awareness of ALS, this month and beyond


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