Chinese study connects past smoking habits to increased risk for ALS

An experimental brain-computer interface that helped a man with amyotrophic lateral sclerosis (ALS) communicate again has earned a neuroscientist at the University of California, Davis, the 2026 Chen Institute and Science Prize for AI Accelerated Research. Sergey Stavisky, PhD, an associate professor in the university’s Department of Neurological Surgery, was…

RAG-17, an experimental RNA-targeting therapy designed to treat amyotrophic lateral sclerosis (ALS) caused by mutations in the SOD1 gene, was generally well tolerated and substantially lowered two disease-related biomarkers in a first-in-human Phase 1 trial involving six people. The investigational therapy also showed promise in animal studies, delaying disease onset…

The anticipated availability and subsequent approval in Canada of the first gene-targeted therapy for certain people with amyotrophic lateral sclerosis (ALS) has transformed how doctors in the North American nation approach genetic testing for the rare neurodegenerative disease, according to a new study. Over the last five years, Canadian…

ALS has taken a lot, but I am thankful I still have my partner in parenting. Our teenage son came home with an injury one morning last week, and I took one look at the gash on his face and thought it needed stitches. My husband, Todd, concurred.

A feature documentary airing on PBS delves into a man’s final years living with amyotrophic lateral sclerosis (ALS), offering an intimate portrait of resilience, caregiving, and enduring love while exploring how culture and identity shaped his experience with the disease. The film “…

I’ve been busy learning how to drive! No, not a four-wheeled automobile — it’s a six-wheeled power wheelchair. Although I continue to rely on a rollator to help me walk inside the house and a mobility scooter when I’m out and about, getting the power wheelchair was a strategic,…

A post-marketing analysis of safety reports found that many of the strongest signals involving Qalsody (tofersen) in people with amyotrophic lateral sclerosis (ALS) were related to the spinal procedures used to administer it. Other reporting signals involved neurological and inflammatory events. The study, based on 409 reports submitted…

A self-balancing, hands-free robotic exoskeleton designed for people with severe gait impairment was safe and well tolerated in a small pilot study of amyotrophic lateral sclerosis (ALS) patients who could still walk. While six weeks of walking practice with the Atalante exoskeleton did…

Targeting a specific part of the TDP-43 protein can prevent toxic protein clumping that drives amyotrophic lateral sclerosis (ALS) without disrupting the protein’s normal function, a new study shows. “Current [U.S.-approved] treatments for ALS provide only modest benefits. There is an urgent need for a real breakthrough,” Xinglong Wang,…