Genetic analysis reveals hidden family ties across ALS and FTD

A pivotal Phase 2/3 clinical trial comparing the experimental oral therapy CB03-154 with a placebo in people with amyotrophic lateral sclerosis (ALS) has completed enrollment in China, developer Zhimeng Biopharma announced. China’s Center for Drug Evaluation (CDE) cleared the trial to begin last year. It…

We’ve had a mild fall on Michigan’s Keweenaw Peninsula with no snow or frost yet, though we often have both before November arrives. But even with our good weather, I’m steeling myself to face the coming winter. I drained my hoses and hung them on the garage wall. I picked…

President Donald Trump has signed into law legislation to renew the Accelerating Access to Critical Therapies (ACT) for amyotrophic lateral sclerosis (ALS), a federal program aimed at supporting ALS research and helping patients access promising experimental therapies. The original ACT for ALS was signed into law in 2021…

A wide range of potentially modifiable factors related to lifestyle, the environment, mental and physical health, and socioeconomic circumstances may be linked to the risk of developing amyotrophic lateral sclerosis (ALS), a study in China suggests. The researchers identified 45 factors significantly associated with ALS in an analysis of…

The ALS Society of Canada is calling on the federal government to invest CAD$50 million over five years in a national initiative aimed at accelerating research, expanding clinical trial access, and advancing the search for treatments for amyotrophic lateral sclerosis (ALS). More than 40 people living with ALS,…

The United States Congress recently passed legislation to support five more years of ALS research and expand access to promising experimental therapies. We cannot afford to waste a moment. On Sept. 28, Congress passed the Accelerating Access to Critical Therapies for ALS (ACT for ALS) Reauthorization Act, which would…

A combination of 10 blood proteins distinguished people with amyotrophic lateral sclerosis (ALS) from healthy people with 98.3% balanced accuracy in a new study. “This 10-protein combination in our ALS disease prediction model classified ALS vs control with superior accuracy … to previously published studies,” researchers wrote. However, the…

Two interconnected themes — community and hope — dominated the conversations at a recent gathering of people living with neuromuscular diseases. Lily Sander, MDA National Ambassador, speaking at MDA Engage: Dallas. (Photo by Tara Haelle) Lily Sander, national ambassador for the Muscular Dystrophy Association (MDA), hit on those…

A history of head injury is associated with 36% higher odds of amyotrophic lateral sclerosis (ALS), according to a systematic review and meta-analysis of 29 studies involving more than 5 million people. The review included 22 studies that compared people with and without ALS, looking at…