Scientists find promising 3 drug combo for sporadic ALS using new models

A triple combination therapy has shown promise for treating sporadic amyotrophic lateral sclerosis (ALS), according to a new study that used cell models of the disease to screen more than 100 therapeutic compounds. The new cell-based model was created from motor neurons, or nerve cells, derived from people with…

My husband, Todd, finally got in his new wheelchair! After it was delivered in September, I wrote that we needed to have the attendant control reprogrammed. That finally happened, and we’ve been fine-tuning the chair over the past week. Although both are the same brand, there are differences between…

For most people, February is a month filled with hearts and flowers. But for me, it’s all that plus a vibrant display of ALS zebras and a splash of green, pink, blue, and purple. Zebras? You might wonder what a striped animal has to do with a neurological disease…

The ALS Society of Canada (ALS Canada) and Brain Canada have awarded a combined $515,000 to support four early-career clinicians and researchers advancing care and scientific understanding of amyotrophic lateral sclerosis (ALS). ALS Canada and Brain Canada have been partners since 2014, with early support stemming from…

The U.S.-based advocacy group I AM ALS has secured $313 million in new federal funding for Push for Progress, an effort the nonprofit launched in late 2025 to accelerate research and expand access to treatments for amyotrophic lateral sclerosis (ALS). In a press release announcing the…

As I cuddle my newborn granddaughter in my arms at the hospital, I murmur to her, telling her that she is perfect and I love her. I tell her about her aunts, uncles, and cousins who are excited to meet her. Despite the impact of bulbar-onset ALS on my…

No U.S. state earned the highest possible score on the ALS Association‘s annual ALS State Policy Report Cards for policies supporting people with amyotrophic lateral sclerosis (ALS) this year, and several averaged failing grades. The report cards are designed to provide a…

Over the past few weeks, it’s been unseasonably and brutally cold here in Maryland, where I live. A severe storm coated much of the state with fluffy snow, then several inches of hazardous ice that hasn’t melted. This might be pretty if it weren’t so treacherous, leading to more accidents…

Glycogen, an inflammatory sugar molecule produced by certain gut bacteria, may play a key role in driving amyotrophic lateral sclerosis (ALS), a study found. Treatments to degrade glycogen reduced inflammation and extended survival in an animal model of the disease, and clinical trials to test this approach in people…

Last night, I had a dream in which my husband, Todd, did not have ALS. It was a bit of sweet respite from my day-to-day life, and I woke up missing that old version of us. In real life, I am Todd’s caregiver. He is completely paralyzed and needs…