Masitinib Alleviates Inflammatory Response Triggered by Schwann Cells in Rat Model of ALS
A recently discovered inflammatory mechanism triggered by Schwann cells —  specialized cells that produce the protective myelin…
Articles by Joana Carvalho, PhD
Blocking SARM1 Prevents Neuronal Degeneration in Mice and Cell Models, Study Shows
Small molecule inhibitors that block the activity of SARM1 — an enzyme that plays a key role in nerve…
Protein Related to ALS Onset Used to Develop New Method of Antibody Validation for Use in Research
Scientists have developed a new method to validate antibodies for research, demonstrating its effectiveness by using the protein encoded by…
First ALS Patient Enrolled in Phase 1 Trial of AP-101, AL-S Pharma AG Announces
AL-S Pharma AG, a biotech company jointly founded and financed by Neurimmune and TVM Capital Life Science, has…
First ALS Patient Enrolled in Phase 2/3 Trial of CuATSM, CMD Announces
Collaborative Medicinal Development (CMD) has enrolled the first patient in its Phase 2/3 clinical trial assessing…
Reldesemtiv Slows Decline in Muscle Control Needed for Speech, Phase 2 Trial Analysis Finds
Use of reldesemtiv in a clinical trial in amyotrophic lateral sclerosis (ALS) patients led to a slower decline in muscle control…
U.S. Department of Defense Earmarks $758,121 to Develop RASRx1902 as Potential ALS Therapy
The U.S. Department of Defense (DoD) has issued a two-year research grant totaling $758,121 to support a group of…
Poorer Outcomes Likely in Those with Rapid Weight Loss Early in ALS Course, Study Suggests
People with rapid weight loss in the earlier stages of amyotophic lateral sclerosis (ALS) — before invasive ventilation is…
New Split-Hand Index Identifies ALS Patients at Early Disease Stages, Study Shows
Scientists have created a new type of split-hand index — which identifies the loss of the pincer grasp — that…
Complete Loss of SOD1 Function Leads to Severe Motor Problems, Study Says in Warning to Researchers
Mutations causing a complete loss of function of the SOD1Â gene lead to severe motor problems, a case study reports,…