MediciNova has presented positive interim data from an ongoing clinical trial to evaluate the efficacy and safety of MN-166 (ibudilast) in the treatment of amyotrophic lateral sclerosis (ALS). The study, entitled “Adaptive Design Single Center Phosphodiesterase Type 4 (PDE4) Inhibitor – Ibudilast (MN-166) Phase 1b/2a Clinical Trial [NCT02238626] for Amyotrophic Lateral…
The Augmentative Communication Program (ACP) at Boston Children’s Hospital has received a $1.5 million donation to set up a program focused on improving the quality of life of amyotrophic lateral sclerosis (ALS) adult patients. ALS is a progressive neurodegenerative disease with no treatment to date. The new program will be dedicated to…
Flex Pharma, Inc., a biotechnology company developing novel proprietary treatments for spasms and nocturnal and exercise muscle cramps associated with severe neuromuscular diseases, like amyotrophic lateral sclerosis (ALS) and motor neuron disease (MND), recently presented data demonstrating the role of efficacy of combinations of two molecules, TRPA1 and TRPV1 agonists, in reducing muscle cramp…
MediciNova, Inc., a biopharmaceutical company that acquires and develops novel, small-molecule therapeutics for diseases with unmet medical needs, recently announced that data from the ongoing clinical trial of MN-166 (ibudilast) in patients with amyotrophic lateral sclerosis (ALS) will be presented at the 6th Annual California ALS Pac10 and Research Network Meeting in January 2016. MN-166…
A new multidisciplinary clinic, the Jefferson Weinberg ALS Center, has announced it will open its doors on January 8th 2016. The new clinic will merge with the already settled Frances and Joseph Weinberg Unit for ALS Research leading to a new comprehensive clinical and research integrated center that will offer patients a…
The first transgenic mouse model for the most common type of the familial form of amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) has been developed by Cedars-Sinai scientists. Their research paper, titled “C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD,” was published in…
In a recent study published in the Journal of Comparative Neurology, researchers found that the same sensory neurons that keep a person from dropping a glass of water are implicated in amyotrophic lateral sclerosis (ALS), and because these neurons are easier to study in the laboratory than motor neurons, they…
MediciNova, Inc. recently announced that the U.S. Food and Drug Administration (FDA) has approved the protocol of a novel clinical trial in patients with amyotrophic lateral sclerosis (ALS) to assess MN-166 (ibudilast) on a biomarker of ALS. The Phase 2a trial, titled “A Single-Center, Open-Label Biomarker Study to…
The winners of the DREAM ALS Stratification Prize4Life Challenge were recently announced by Prize4Life, Sage Bionetworks and the DREAM community. The challenge is a global data analysis competition designed to computationally determine the different subgroups of patients who suffer from amyotrophic lateral sclerosis (ALS). There is currently…
Researchers at the University of Edinburgh studied the effect of the hormone serotonin in the regeneration of motor neurons after spinal cord injury that may one day hold implications in amyotrophic lateral sclerosis (ALS), part of a large group of motor neuron diseases. The research paper, entitled “Serotonin Promotes Development…
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