Patient enrollment is now complete in an arm of the HEALEY ALS platform trial that’s testing Denali Therapeutics‘ DNL343 for the treatment of adults with amyotrophic lateral sclerosis (ALS). The HEALEY platform trial (NCT04297683), led by the Sean M. Healey & AMG Center…
Epigenetic changes — chemical modifications in DNA that alter gene activity — in nerve cells from people with amyotrophic lateral sclerosis (ALS) may be associated with the rate of disease progression, a study suggested. Changes in certain regions of a patient’s nerve cell genome were able “to predict ALS…
Alejandra Zeballos, a PhD student in bioengineering at the University of Illinois Urbana-Champaign, was awarded the 2024 Illinois Innovation Award for her work on next-generation therapies to advance the treatment of amyotrophic lateral sclerosis (ALS). Zeballos, a member of the Gaj Lab, has been working…
PrimeC, a treatment candidate for amyotrophic lateral sclerosis (ALS), was found to significantly slow disease progression in certain subgroups of patients in the ongoing PARADIGM Phase 2b trial, according to new data announced by its developer NeuroSense Therapeutics. Benefitting most were people at high risk of rapid disease…
University of Michigan neurologist Eva Feldman was recently recognized with the 2024 Sheila Essey Award for her groundbreaking research on the biological processes that drive the onset of amyotrophic lateral sclerosis (ALS) and its progression. The award, announced at the American Academy of Neurology (AAN) 2024 Annual Meeting, recognizes…
The ALS Multidisciplinary Clinic at the University of Cincinnati Gardner Neuroscience Institute in Ohio has been gifted $13.5 million to advance its research and patient care initiatives related to amyotrophic lateral sclerosis (ALS). The donation comes from the estate of Hugh H. Hoffman, who earned a degree from the…
The Tambourine ALS Breakthrough Research Fund has committed more than $5 million in funding to eight research projects aiming to better understand, diagnose, and treat amyotrophic lateral sclerosis (ALS). A first call for proposals was launched in May 2023 by Tambourine Philanthropies, a charitable foundation established by…
A blood biomarker of oxidative stress, a type of cellular stress implicated in amyotrophic lateral sclerosis (ALS), is significantly increased in ALS patients and its levels seem to correlate with disease progression and survival. That’s according to a recent analysis of study data from Coya Therapeutics, with the…
Scientists at Stony Brook University aim to create a caregiving robot assistant (CART) to help people with amyotrophic lateral sclerosis (ALS) and their caregivers with everyday tasks. Led by I.V. Ramakrishnan, PhD, a professor of computer science and associate dean at the university’s College of Engineering and Applied Sciences,…
May marks amyotrophic lateral sclerosis (ALS) awareness month, a time dedicated to raising awareness about ALS and answering the call to support those affected by the neurodegenerative disease. In the U.S. and internationally, baseball games, conferences, flag raisings, and community events are held during ALS Awareness Month to honor…
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