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FYI – Several excellent threads at the ALS-TDI Forums (https://www.als.net/forum/) discuss the link between mitochondrial health and ALS pathologies and suggest a number of potential therapeutic strategies.
The most comprehensive is clearly the discussion started back in 2014 by an excellent contributor Barbarawanda titled – Quality control of mitochondria in neurons
Other more recent threads include:
Melatonin is produced in the mitochondria and that may be for a good reason…….
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On a personal note, my wife is in her 12th year of Bulbar-onset ALS. For a number of reasons, we are very big believers in NAD+ elevation strategies – not only for promoting mitochondrial and metabolic health, but also its critical role as a sirtuin cofactor. For this, we also use pterostilbene as a sirtuin co-activator (think resveratrol). I suggest that melatonin supplementation should also be considered.
Reviewed: “NAD+ in brain aging and neurodegenerative disorders” https://pubmed.ncbi.nlm.nih.gov/31577933/
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A pilot study of the NAD+ precursor Nicotinamide Riboside + pterostilbene conducted in Spain in 2017 was very promising: (https://www.tandfonline.com/eprint/5j6sIsrMDYd37hjpNghx/full?target=10.1080%2F21678421.2018.1536152&😉
A Phase 2 equivalent trial is currently recruiting in Norway: ClinicalTrials.gov Identifier: NCT04562831
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Cheers and Good Luck to all ~ Dave